Importance of crystallinity of anchoring block of semi-solid amphiphilic triblock copolymers in stabilization of silicone nanoemulsions

Methods for producing microstructured hydrogels for targeted applications in biology

“…Hydrophobic polymers such as poly(caprolactone), poly(lactide), and poly(hydroxypropyl methacrylate) and hydrophilic polymers like poly(glycerol) and poly(ethylene oxide) are the most commonly used combination for producing the copolymer emulsifiers [198][199][200]. Triblock copolymers involving two different hydrophobic polymers and one hydrophilic have also been used to take advantage of the crystallization of the lipophilic moieties, which reinforces both the steric and elastic effects in the stabilization process [76]. Amphiphilic polypeptides have been used as well for emulsion stabilization.…”

“…While many of the main applications of this technique are largely focused on extraction and purification of material such as DNA [65,66], proteins [67][68][69], and metals [70], the opportunities are significant for producing microstructured hydrogel materials with biomedical applications such as drug delivery and tissue regeneration [71][72][73] or even to form synthetic membraneless organelles for modeling intracellular processes [74]. Limitations of LLPS include a loss of temporal control over the microstructure due to rapid phase separation [73,75], and biocompatible approaches to overcome this issue have been based mainly on interface stabilization by copolymers [76] and Pickering particles [77]. Besides interfacial stabilizers, there are a wide variety of chemical reactions used in hydrogel crosslinking that can arrest the phase separation, with the already mentioned Michael-type addition and photocrosslinking reactions as particularly useful options due to their fast reaction kinetics [78,79].…”

Highly Robust Multilamellar Lipid Vesicles Generated through Intervesicular Self-Assembly Mediated by Hydrolyzed Collagen Peptides

“…Finally, the dispersion stability of LUVs and MCLVs was examined under repeated freeze–thaw cycles and freeze-drying, which are very harsh conditions for colloids . The mean diameter of the lipid vesicles was measured during five repetitions of freezing and thawing for 10 and 5 h, respectively (Figure S7a).…”

“…Finally, the dispersion stability of LUVs and MCLVs was examined under repeated freeze−thaw cycles and freezedrying, which are very harsh conditions for colloids. 32 The mean diameter of the lipid vesicles was measured during five repetitions of freezing and thawing for 10 and 5 h, respectively (Figure S7a). While DOTAP LUVs exhibited a dramatic increase in hydrodynamic size even after the first cycle, DOTAP/CNP LUVs and all MCLVs maintained sub-micron sizes and were still well dispersed up to four cycles.…”