Importance of circadian rhythmicity in the cholinergic treatment of Alzheimer's disease: focus on galantamine

Nieoullon, A.; Bentué-Ferrer, Danièle; Bordet, Régis; Tsolaki, Magda; Förstl, Hans

doi:10.1185/03007990802522397

Cited by 37 publications

(27 citation statements)

References 77 publications

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“…Circadian rhythms are often disturbed in patients with Alzheimer's disease [6]. In addition, modulating the natural circadian fluctuations of central cholinergic transmission is an important factor for improvement when using galanthamine to stimulate central cholinergic transmission in Alzheimer's disease [36]. Here, we showed that Lycoris alkaloids also have an acetylcholinesterase inhibition activity [13] and elongate the circadian period ( Fig.…”

Section: Chronotherapeutic Insight Into Phyto-alkaloidsmentioning

confidence: 66%

Lycorine, a Candidate for the Control of Period Length in Mammalian Cells

Onishi

Kawano²,

Yamazaki³

2012

Cell Physiol Biochem

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Plants of the Amaryllidaceae family have been used as therapeutic agents against CNS related maladies such as Alzheimer′s disease. The known primary alkaloid constituents have significant biological activity. We identified the Lycoris alkaloids lycorine and lycoricidinol from Amaryllidaceae using a real-time reporter gene assay system based on NIH3T3 cells. These alkaloids have a wide spectrum of pharmacological actions and dose-dependently lengthen the circadian period. When cells that had been incubated with lycorine or lycoricidinol were washed and then incubated without these alkaloids, period length reverted to that of control cells, suggesting that elongation of the circadian period induced by lycorine and lycoricidinol is reversible. Although one of its major activities is the inhibition of protein synthesis, lycorine induced dose-dependent period elongation regardless of the presence of cycloheximide and moreover, cycloheximide, itself did not affect period length, suggesting that lycorine dose-dependently extends the circadian period by a mechanism other than translational inhibition. Real-time RT-PCR showed that lycorine enhanced RORα and Bmal1 transcription, and exogenous expression and knockdown of Bmal1 also caused long and short periods, respectively, thus confirming the phenotype indicated by lycorine. These data indicate that lycorine and lycoricidinol modulate Bmal1 transcription and the circadian period, and also suggest that Lycoris alkaloids are novel contributors to the control of period length in mammalian cells.

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Section: Chronotherapeutic Insight Into Phyto-alkaloidsmentioning

confidence: 66%

Lycorine, a Candidate for the Control of Period Length in Mammalian Cells

Onishi

Kawano²,

Yamazaki³

2012

Cell Physiol Biochem

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“…Conversely, in both of our patients the appearance of neurodegenerative process was followed by a significant improvement of all narcoleptic symptoms, including EDS and cataplexy. EDS's paradoxical improvement, as already reported [17] , may be due to the overall sleep improvement and sleep-wake cycle regulation following cholinergic treatment. Interestingly, cataplexy is also mediated by the cholinergic system, and usually responds to anti-cholinergic drugs, while in our case, cataplexy was improved by an enhancement of the cholinergic system.…”

Section: Discussionmentioning

confidence: 66%

Development of Parkinson and Alzheimer Diseases in Two Cases of Narcolepsy-Cataplexy

et al. 2012

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“…In addition to circadian alterations occurring with normal aging, neurodegenerative disorders associated with aging, including Alzheimer's, Parkinson's, and Huntington's diseases, are correlated with disordered circadian rhythms and disrupted sleep patterns (Hatfield et al 2004;Nieoullon et al 2008;Wulff et al 2010;Cermakian et al 2011;Videnovic et al 2014;Musiek 2015). Traditionally, circadian and sleep disorders associated with neurodegenerative diseases have been viewed as symptomatic of these diseases as circadian disorders often correlate with disease severity and rhythms deteriorate with disease progression.…”

Section: The Circadian Clock Aging and Neurodegenerative Diseasesmentioning

confidence: 99%

Synchrony and desynchrony in circadian clocks: impacts on learning and memory

Krishnan

Lyons

2015

Learn. Mem.

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Circadian clocks evolved under conditions of environmental variation, primarily alternating light dark cycles, to enable organisms to anticipate daily environmental events and coordinate metabolic, physiological, and behavioral activities. However, modern lifestyle and advances in technology have increased the percentage of individuals working in phases misaligned with natural circadian activity rhythms. Endogenous circadian oscillators modulate alertness, the acquisition of learning, memory formation, and the recall of memory with examples of circadian modulation of memory observed across phyla from invertebrates to humans. Cognitive performance and memory are significantly diminished when occurring out of phase with natural circadian rhythms. Disruptions in circadian regulation can lead to impairment in the formation of memories and manifestation of other cognitive deficits. This review explores the types of interactions through which the circadian clock modulates cognition, highlights recent progress in identifying mechanistic interactions between the circadian system and the processes involved in memory formation, and outlines methods used to remediate circadian perturbations and reinforce circadian adaptation.Circadian clocks permit organisms to anticipate recurring daily environmental events through the coordination of metabolic, physiological, and behavioral rhythms. Conservation of the core principles through which circadian oscillators are organized across eukaryotic phyla suggests strong selective pressures for both circadian clocks and the mechanisms through which circadian oscillators operate. Intracellularly, transcription/translation feedback loops involving core circadian components set the stage for transcriptional regulation of thousands of genes in individual cells and tissues (Balsalobre et al.

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Importance of circadian rhythmicity in the cholinergic treatment of Alzheimer's disease: focus on galantamine

Cited by 37 publications

References 77 publications

Lycorine, a Candidate for the Control of Period Length in Mammalian Cells

Lycorine, a Candidate for the Control of Period Length in Mammalian Cells

Development of Parkinson and Alzheimer Diseases in Two Cases of Narcolepsy-Cataplexy

Synchrony and desynchrony in circadian clocks: impacts on learning and memory

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