Background: Professional quality of life (ProQoL) is the balance between compassion satisfaction (CS) and compassion fatigue (CF). The experience of CF results from secondary traumatic stress stemming from compassionate caregiving and burnout.Purpose: This study sought to identify the ProQoL of nurse educators and what conditions for work effectiveness affect this ProQoL.Methods: An email survey link was sent to nurse educators from the northeastern region of the United States asking for participation. This included demographics, the ProQoL Version 5, and the Conditions for Work Effectiveness Questionnaire version II (CWEQ-II). Results: The 211 nurse educators reported relatively high CS and relatively low burnout and secondary traumatic stress. When the measures of the CWEQ-II increased, so did their CS. In addition, as the measures of the CWEQ-II increased, their secondary traumatic stress and burnout decreased. Conclusions: Findings suggest that conditions for work effectiveness such as access to opportunity, resources, information, support, and formal and informal power have a relationship to the nurse educator's ProQoL.