CONTEXT: The prevalence of obesity among adolescents has increased and we lack effective treatments. OBJECTIVE: To determine if gastric bypass is safe and effective for an unselected cohort of adolescents with morbid obesity in specialized health care. DESIGN, SETTING AND PATIENTS: Intervention study for 81 adolescents (13-18 years) with a body mass index (BMI) range 36-69 kg m À 2 undergoing laparoscopic gastric bypass surgery in a university hospital setting in Sweden between April 2006 and May 2009. For weight change comparisons, we identified an adult group undergoing gastric bypass surgery (n ¼ 81) and an adolescent group (n ¼ 81) receiving conventional care. MAIN OUTCOME MEASUREMENTS: Two-year outcome regarding BMI in all groups, and metabolic risk factors and quality of life in the adolescent surgery group. RESULTS: Two-year follow-up rate was 100% in both surgery groups and 73% in the adolescent comparison group. In adolescents undergoing surgery, BMI was 45.5 ± 6.1 (mean ± s.d.) at baseline and 30.2 (confidence interval 29.1-31.3) after 2 years (Po0.001) corresponding to a 32% weight loss and a 76% loss of excess BMI. The 2-year weight loss was 31% in adult surgery patients, whereas 3% weight gain was seen in conventionally treated adolescents. At baseline, hyperinsulinemia (420 mU l À 1 ) was present in 70% of the adolescent surgery patients, which was reduced to 0% at 1 year and 3% at 2 years. Other cardiovascular risk factors were also improved. Two-thirds of adolescents undergoing surgery had a history of psychopathology. Nevertheless, the treatment was generally well tolerated and, overall, quality of life increased significantly. Adverse events were seen in 33% of patients. CONCLUSIONS: Adolescents with severe obesity demonstrated similar weight loss as adults following gastric bypass surgery yet demonstrating high prevalence of psychopathology at baseline. There were associated benefits for health and quality of life. Surgical and psychological challenges during follow-up require careful attention.International Journal of Obesity (2012Obesity ( ) 36, 1388Obesity ( -1395 doi:10.1038/ijo.2012; published online 25 September 2012Keywords: adolescent; bariatric; surgery; gastric bypass
INTRODUCTIONThe health consequences for adolescents with obesity are serious. There is an increased risk of cardiovascular and endocrine disorders, metabolic syndrome, various cancers and psychosocial problems. [1][2][3] Taken together, quality of life and life expectancy are reduced. 4 Yet behavioral intervention constitutes the cornerstone of childhood and adolescent obesity treatment, 3 the results for adolescents are modest. 5 Among severely obese adolescents, favorable effects of non-surgical treatment seem to be very limited and clearly insufficient for long-term reduction of the health hazards associated with obesity. 6,7 Bariatric surgery in adults results in long-term weight loss, decrease in mortality and morbidity and improvements in quality of life. [8][9][10][11] However, surgery is not generally endorsed u...