The objective of this study is to find out the impact of instrumentation and control (I&C) components on the availability of I&C systems in terms of sensitivity analysis using Bayesian network. The analysis has been performed on I&C architecture of reactor protection system. The analysis results would be applied to develop I&C architecture which will meet the desire reliability features and save cost. RPS architecture unavailabilityP(x=0)and availabilityP(x=1)were estimated to6.1276E-05and9.9994E-01for failure (0) and perfect (1) states, respectively. The impact of I&C components on overall system risk has been studied in terms of risk achievement worth (RAW) and risk reduction worth (RRW). It is found that circuit breaker failure (TCB), bi-stable processor (BP), sensor transmitter (TR), and pressure transmitter (PT) have high impact on risk. The study concludes and recommends that circuit breaker bi-stable processor should be given more consideration while designing I&C architecture.