Implicit and explicit emotional memory recall in anxiety and depression: Role of basolateral amygdala and cortisol-norepinephrine interaction

Hakamata, Yuko; Mizukami, Shinya; Izawa, Shuhei; Okamura, Hisayoshi; Mihara, Kengo; Marusak, Hilary A.; Moriguchi, Yoshiya; Hori, Hiroaki; Hanakawa, Takashi; Inoue, Yusuke; Tagaya, Hirokuni

doi:10.1016/j.psyneuen.2021.105598

Cited by 21 publications

(17 citation statements)

References 60 publications

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“…On the other hand, a positive association was observed between trait anxiety and cortisol secretion [ 44 ]. Furthermore, a synergistic effect of the functional connectivity between the basolateral nucleus of the amygdala and the pregenual anterior cingulate cortex in the brain on the stress hormones cortisol and norepinephrine has been suggested to be involved in the mechanism facilitating the recall of negatively biased memories that underlies depressive rumination [ 45 ]. Therefore, the experience of childhood victimization may induce the oversecretion of cortisol, which damages the brain and weakens its function, triggering depressive rumination and trait anxiety.…”

Section: Discussionmentioning

confidence: 99%

Depressive rumination and trait anxiety mediate the effects of childhood victimization on adulthood depressive symptoms in adult volunteers

et al. 2023

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Background Prior studies have reported that childhood victimization experiences substantially augment the risk of depression and suicide in adulthood. Several of our previous studies suggested that childhood experiences of victimization interact with the quality of parenting experienced in childhood, childhood experiences of abuse, neuroticism, and other factors to influence depressive symptoms in adulthood. In this study, it was hypothesized that “childhood victimization” worsens “trait anxiety” and “depressive rumination”, and that “trait anxiety” and “depressive rumination” are mediators that worsen “depressive symptoms in adulthood”. Subjects and methods The following self-administered questionnaires were completed by 576 adult volunteers: Patient Health Questionnaire-9, State–Trait Anxiety Inventory form Y, Ruminative Responses Scale, and Childhood Victimization Rating Scale. Statistical analyses were performed by Pearson correlation coefficient analysis, t-test, multiple regression analysis, path analysis, and covariance structure analysis. Results Path analysis demonstrated that the direct effect was statistically significant for the paths from childhood victimization to trait anxiety, depressive rumination, and depressive symptom severity. Moreover, the indirect effect of childhood victimization on depressive rumination mediated by trait anxiety was statistically significant. The indirect effects of childhood victimization on depressive symptom severity mediated by trait anxiety and depressive rumination were statistically significant. Furthermore, the indirect effect of childhood victimization on depressive symptom severity mediated by both trait anxiety and depressive rumination was statistically significant. Conclusions We found that childhood victimization directly and adversely influenced each of the above factors, and indirectly worsened adulthood depressive symptoms with trait anxiety and depressive ruminations as mediating factors. The present study is the first to clarify these mediation effects. Therefore, the results of this study suggest the importance of preventing childhood victimization and the importance of identifying and addressing childhood victimization in patients with clinical depression.

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Section: Discussionmentioning

confidence: 99%

Depressive rumination and trait anxiety mediate the effects of childhood victimization on adulthood depressive symptoms in adult volunteers

et al. 2023

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“…In short, individual functional neural connective patterns of the amygdala-hippocampal-pgACC circuit could play a role in the complicated link between cortisol and emotional-related behaviors [ 44 ]. A recent report suggested that the basolateral amygdala to subgenual anterior cingulate cortex neural connectivity and the cortisol–norepinephrine interaction, which may be associated with implicit memory bias, could be one of the pathophysiologies of anxiety disorders and MDD [ 45 ]. BDNF is known to regulate synaptic plasticity and memory formation in many areas of the brain, including the amygdala, where BDNF signaling via tyrosine kinase B receptor (TrkB) is prominently involved in fear learning [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Volume of Amygdala Subregions and Plasma Levels of Brain-Derived Neurotrophic Factor and Cortisol in Patients with s/s Genotype of Serotonin Transporter Gene Polymorphism of First-Episode and Drug-Naive Major Depressive Disorder: An Exploratory Study

Okamoto

Watanabe

Tesen

et al. 2022

Neurology International

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The amygdala is a prominent region of the brain that plays a critical role in the pathophysiology of major depressive disorder (MDD). The amygdala is formed from a collection of interconnected substructures (nuclei) that relay signals from multiple brain areas, which suggests that the amygdala has different functions depending on its subregion. There are two main alleles of serotonin transporter gene polymorphism (5-HTTLPR): a 44-bp insertion (l-allele) or deletion (s-allele). The transcriptional activity of the l-allele of the gene is twice that of the s-allele. The present study aimed to investigate the association between the volume of the whole amygdala and subregions of the amygdala in 25 first-episode and drug-naive patients with MDD and 46 healthy controls (HCs) with the s/s genotype of 5-HTTLPR and plasma levels of brain-derived neurotrophic factor (BDNF) or cortisol. No significant difference was observed in the amygdala total and subregion volumes between the HC and MDD groups. No significant difference was found in the plasma levels of BDNF and cortisol between the two groups. In addition, no correlations were found between the total and subregion amygdala volume and plasma levels of cortisol or BDNF.

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“…Arnaud et al 2 2022 Relação da depressão com doenças neurodegenerativas como o alzheimer. Filatova et al 3 2021 Mecanismos e relações comuns de todas as teorias envolvidas na patogênese da depressão Sousa Júnior et al 5 2021 Estresse, memória e implicações na depressão maior Sneider et al 6 2021 Alterações estruturais e funcionais no hipocampo e lobo frontal relatadas no Transtorno Depressivo Maior Hakamata et al 7 2021 Memória implícita e explícita, papel da amígdala e interação cortisolnoroepinefrina Price et al 8 2020 Neuroplasticidade dos mecanismos cognitivos e psicológicos da depressão Nikolin et al 9 2021 Deficiência da memória de trabalho na depressão Chao OY et al 10 2020 Propriedades comportamentais, anatômicas e neuroquímicas na construção da memória episódica Fiksdal et al 11 2019 Relação entre os sintomas de depressão e ansiedade e respostas do cortisol Fries et al 12 2022 As vias moleculares do transtorno depressivo maior convergem na sinapse Nakamura et al 13 2023 Memória emocional associada à indução de transtornos mentais como a depressão Nandam et al 14 2020 Cortisol e Transtorno Depressivo Maior Tartt et al 15 2022 Desregulação do hipocampo adulto na neuroplasticidade do Transtorno depressivo maior Zarembra et al 16 2019 Os efeitos da velocidade de processamento no comprometimento da memória em pacientes com transtorno depressivo maior Zhao et al 17 2020 Efeitos a longo prazo do estresse pós-traumático na adolescência no desenvolvimento de dendritos, hipocampo e córtex pré-frontal Mulheres são mais propensas a ter episódios depressivos quando comparadas aos homens 18,22 Fonte: Elaboração própria.…”

Section: Autor Ano Mecanismo Fisiopatológico Da Depressão Relacionado...unclassified

“…A princípio, diversos mecanismos neurais coordenam a vida diária através de diferentes sistemas da memória, o estresse ou emoções negativas desempenham um papel fundamental no armazenamento da memória por meio de estruturas cerebrais como o hipocampo, amígdala e córtex cerebral [5][6][7] .…”

Section: Introductionunclassified

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Mecanismos fisiopatológicos da depressão relacionados à perda de memória

Oliveira Mateus,

Nolasco Marques,

Alves de Freitas

et al. 2024

Rev Neurocienc

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Introdução. A depressão é definida como uma doença psiquiátrica de caráter multifatorial que afeta mais de 300 milhões de pessoas e possui sintomas como humor deprimido. Pode ser desencadeada de eventos estressantes e impactar significativamente algumas etapas fisiológicas da memória como na evocação, velocidade de processamento e armazenamento associado a funcionalidades aberrantes hipocampais. Objetivo. Evidenciar os prejuízos da depressão relacionados aos aspectos emocionais e cognitivos que comprometem a memória abordados a partir de anormalidades neurofisiológicas. Método. Revisão de literatura integrativa elaborada por meio de pesquisas utilizando as bases de dados da Scielo, PubMed, LILACS, BVS e Science Direct, com os seguintes descritores “Fisiologia” e “Depressão” e “Memória” no período de 2018-2023 e foram selecionados 26 artigos de acordo com o título, resumo, ano de publicação, tipo de estudo, idioma e concordância com o tema. Resultados. A revisão de literatura foi executada quanto à associação entre a fisiopatologia da depressão e à perda da memória, a epidemiologia, o caráter fisiopatológico da depressão e foi descrito as várias facetas fisiológicas da memória. Conclusão. Portanto, esse artigo aborda um tema de extrema importância visto que as manifestações patológicas na memória como o impacto neurocognitivo devido à depressão são sintomas relevantes que impactam a vida do indivíduo.

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Implicit and explicit emotional memory recall in anxiety and depression: Role of basolateral amygdala and cortisol-norepinephrine interaction

Cited by 21 publications

References 60 publications

Depressive rumination and trait anxiety mediate the effects of childhood victimization on adulthood depressive symptoms in adult volunteers

Depressive rumination and trait anxiety mediate the effects of childhood victimization on adulthood depressive symptoms in adult volunteers

Volume of Amygdala Subregions and Plasma Levels of Brain-Derived Neurotrophic Factor and Cortisol in Patients with s/s Genotype of Serotonin Transporter Gene Polymorphism of First-Episode and Drug-Naive Major Depressive Disorder: An Exploratory Study

Mecanismos fisiopatológicos da depressão relacionados à perda de memória

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