Implications of vitamin D deficiency in systemic inflammation and cardiovascular health

Dey, Sanjay Kumar; Kumar, Shashank; Rani, Diksha; Maurya, Shashank Kumar; Banerjee, Pratibha; Verma, Madhur; Senapati, Sabyasachi

doi:10.1080/10408398.2023.2224880

Cited by 8 publications

(2 citation statements)

References 184 publications

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“…Vitamin D is a steroid hormone that is deficient in humans and is associated with conditions such as hypertension, cardiovascular events, myocardial infarction, stroke, and cancer. 6 It is biologically inactive and needs to function via two‐step hydroxylation to 1,25‐hydroxyvitamin D (25(OH)D). Furthermore, 25(OH)D is an intermediate product, and the level of vitamin D is typically assessed by measuring its concentration in the human body.…”

Section: Introductionmentioning

confidence: 99%

An inverse causal relationship between serum 25‐hydroxyvitamin D levels and pulmonary hypertension: A two‐sample Mendelian randomization study

Chao,

Wang,

Mei

et al. 2024

Pulm. circ.

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Observational studies have confirmed that 25‐hydroxyvitamin D (25(OH)D) is associated with pulmonary hypertension (PH), but the causal association between each other is unclear. Therefore, Mendelian randomization (MR) method was performed to validate the causal association between PH and serum 25(OH)D levels. The summary data for 25(OH)D and PH were from the National Human Genome Research Institute‐European Bioinformatics Institute. Catalog of human genome‐wide association studies and FinnGen biobank consortium. MR analysis was utilized to explore the potential causal association between PH and 25(OH)D. To evaluate this association, inverse variance weighting was considered as the primary method. Cochran's Q test, MR‐Egger intercept test, and “leave‐one‐out” sensitivity analyses were utilized to control the pleiotropy and heterogeneity in the study. Two‐sample MR analysis revealed an inverse causal relationship between 25(OH)D and PH (odds ratio: 0.376, 95% confidence interval: 0.162–0.876, p = 2.334 × 10−2). There was no significant heterogeneity and pleiotropy. The present study confirmed the inverse causal relationship between 25(OH)D and PH. This pathway may provide another treatment pathway in PH. Further studies to elucidate this pathway is indicated.

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Section: Introductionmentioning

confidence: 99%

An inverse causal relationship between serum 25‐hydroxyvitamin D levels and pulmonary hypertension: A two‐sample Mendelian randomization study

Chao,

Wang,

Mei

et al. 2024

Pulm. circ.

View full text Add to dashboard Cite

show abstract

“…While the phenotypic activity of active forms of VD is predominantly mediated through the vitamin D receptor (VDR) [6,9], they can also regulate phenotype through alternative nuclear receptors, including retinoic acid receptor-related orphan receptor alpha/gamma (ROR α/γ) and liver X receptor alpha/beta (LXR α/β) [10]. Given that ROR α/γ and LXR α/β play critical regulatory roles in lipid metabolism, it is plausible that VD may be associated with the risk of chronic diseases such as MetS, CVD, and diabetes [11]. Consequently, VD supplementation and VD-fortified foods may help reduce the risk of these diseases.…”

Section: Introductionmentioning

confidence: 99%

Insight into the Interaction Mechanism of Vitamin D against Metabolic Syndrome: A Meta-Analysis and In Silico Study

Xia,

Yu,

Zhao

et al. 2023

Foods

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As a dietary supplement or functional food additive, vitamin D (VD) deficiency may impact extra-skeletal functions associated with metabolic syndrome (MetS) risk factors. However, the precise effects and mechanisms of VD supplementation on dyslipidemia and insulin resistance in MetS subjects remain controversial. Here, we investigate potential therapeutic targets, pathways and mechanisms of VD against MetS through a comprehensive strategy including meta-analysis, network pharmacology analysis, molecular docking, dynamics simulations, and quantum chemical calculations. Our results reveal that VD supplementation significantly reduces triglyceride levels, fasting glucose, and insulin concentrations in subjects, thereby improving insulin homeostasis to some extent. We theoretically identify 14 core MetS-associated targets. Notably, VD exhibits substantial interactions with three targets (PPARγ, FABP4, and HMGCR) in the PPAR signaling pathway, indicating that VD can modulate this pathway. Van der Waals forces predominantly stabilize the complexes formed between VD and the three targets. Nonetheless, to provide valuable insights for personalized MetS management, further research is necessary to confirm our findings, emphasizing the importance of exploring genetic variability in VD response. In conclusion, our study contributes insights into the mechanisms of VD in preventing and treating MetS through dietary supplementation, promoting the development of VD-based functional foods or nutritious diets.

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Translational bioinformatics approach to combat cardiovascular disease and cancers

Shahjahan,

Dey,

Dey

2024

Advances in Protein Chemistry and Structural Biology

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Implications of vitamin D deficiency in systemic inflammation and cardiovascular health

Cited by 8 publications

References 184 publications

An inverse causal relationship between serum 25‐hydroxyvitamin D levels and pulmonary hypertension: A two‐sample Mendelian randomization study

An inverse causal relationship between serum 25‐hydroxyvitamin D levels and pulmonary hypertension: A two‐sample Mendelian randomization study

Insight into the Interaction Mechanism of Vitamin D against Metabolic Syndrome: A Meta-Analysis and In Silico Study

Translational bioinformatics approach to combat cardiovascular disease and cancers

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