2021
DOI: 10.1136/bmjresp-2021-001135
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Implications of using the GLI-2012, GOLD and Australian COPD-X recommendations in assessing the severity of airflow limitation on spirometry among an Indigenous population with COPD: an Indigenous Australians perspective study

Abstract: BackgroundAssessment of airflow limitation (AFL) is crucial in the clinical evaluation of patients with chronic obstructive pulmonary disease (COPD). However, in the absence of normative reference values among adult Australian Indigenous population, the implications of utilising the Global Lung Function Initiative (GLI-2012), Global Initiative for Chronic Obstructive Lung Disease (GOLD) and the Australian concise COPD-X recommended severity classifications is not known. Moreover, spirometry values (forced vita… Show more

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Cited by 14 publications
(24 citation statements)
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“…Varying manifestations of sex differences in PFTP’s have been demonstrated in this study, both with and without underlying radiological evidence of CADs among an Indigenous Australian cohort. This could also have implications in classifying severity of CADs [ 51 ] and in the clinical decision making while considering airway directed inhaled pharmacotherapy [ 52 ]. We believe the results represented in this study may be an avenue or encourage other researchers in characterising sex differences in other Indigenous populations, with a view to establishing normative reference lung function values for adult Indigenous population.…”
Section: Discussionmentioning
confidence: 99%
“…Varying manifestations of sex differences in PFTP’s have been demonstrated in this study, both with and without underlying radiological evidence of CADs among an Indigenous Australian cohort. This could also have implications in classifying severity of CADs [ 51 ] and in the clinical decision making while considering airway directed inhaled pharmacotherapy [ 52 ]. We believe the results represented in this study may be an avenue or encourage other researchers in characterising sex differences in other Indigenous populations, with a view to establishing normative reference lung function values for adult Indigenous population.…”
Section: Discussionmentioning
confidence: 99%
“…A recent study has highlighted, irrespective of which of the recommended classifications used, COPD-X 46 or GOLD, 1 most Indigenous patients with COPD will likely fall into either the “severe” or “very severe” category. 22 Indigenous patients in this study demonstrated 16–17% lower values for FVC and FEV 1 , compared to non-Indigenous patients. It is inevitable that an Indigenous patient with COPD will likely be assessed to have a higher disease burden by adopting spirometry reference values for the non-Indigenous population.…”
Section: Discussionmentioning
confidence: 49%
“…There has been significant progress in the recent past in addressing respiratory health issues among the adult Indigenous Australian population, especially, from the Top End NT of Australia. 7–11 , 14–17 , 21 , 22 , 47–59 Further studies, however, may be useful to better understand if our study findings are comparable to other Indigenous population both in other parts of Australian and globally, that may change the diagnostic and management of COPD paradigm among Indigenous populations.…”
Section: Discussionmentioning
confidence: 76%
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