Implications of the variation in biological 18O natural abundance in body water to inform use of Bayesian methods for modelling total energy expenditure when using doubly labelled water
Abstract:RationaleVariation in 18O natural abundance can lead to errors in the calculation of total energy expenditure (TEE) when using the doubly labelled water (DLW) method. The use of Bayesian statistics allows a distribution to be assigned to 18O natural abundance, thus allowing a best‐fit value to be used in the calculation. The aim of this study was to calculate within‐subject variation in 18O natural abundance and apply this to our original working model for TEE calculation.MethodsUrine samples from a cohort of … Show more
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