Implications of the transcription factor WT1 linked to the pathologic cardiac remodeling post-myocardial infarction

Sanz, Raúl; Mazzei, Luciana; Manucha, Walter

doi:10.1016/j.artere.2019.05.002

Cited by 4 publications

(3 citation statements)

References 26 publications

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“…Low Vit D level has been documented to have comparable prognostic importance in critically admitted patients, with an association between illness severity and mortality of AMI. 12,13 Together, these results confirm the theory that Vit D plays a role in the emergence of cardiac risk factors, contributing to worsening AMI patients' short-and long-term prognosis. 14 However, the correlation between Vit D status and clinical outcomes in AMI patients has only been the focused of a few studies.…”

Section: Introductionsupporting

confidence: 76%

Association of Serum Vit D level with in-Hospital Outcome in Patients with Acute Myocardial Infarction

Din,

Haq,

Adeel

et al. 2023

PJMHS

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Background: Low Vitamin D (Vit D) level is associated with disease severity amongst critical acute myocardial infarction (AMI) patients. This leads to the hypothesis that Vit D plays a role in the emergence of cardiac risk factors, contributing to worsening AMI patients' short- and long-term prognoses. Therefore, there is still unclear data showing the potential impact of Vit D insufficiency or deficiency on the morbidity and mortality of AMI patients. So far, there has been no research conducted in Pakistan examining whether or not Vit D status are association to the outcome of hospitalization for coronary artery disease. Objective: The objective of the study is to examine the relationship between Vit D status on hospital admission and subsequent mortality and morbidity among patients with acute myocardial infarction. Study Design: Cross sectional observational study Study Setting: This study was conducted in the department of Interventional Cardiology, National Institute of Cardiovascular Diseases (NICVD), Karachi from Ist August 2022 to 31st January 2023. Methodology: Total 250 subjects were enrolled in the study and divided in to two groups. Group A with normal Vit D (30ng/ml or above) and Group B included lower Vit D level than 30ng/ml, all patients were suffering from AMI. Baseline demographic characteristics, including age, and gender (male/female), was recorded. The patients were tested for Vit D status and distributed in their respective groups. The history, complications, and clinical data were included. The stay in the hospital and any adverse outcomes that appeared during the stay were also recorded. The clinical results include HDL, TG, and troponin I of every patient were noted for the clinical correlation of AMI patients with adequate and deficiency of Vit D level. All the data was collected in the form of a questionnaire. The statistical analysis was done by using SPSS version 20. Results: Participants' mean ages were 53.8 and 5.9 years old. Group A (patients with low Vit D status) averaged 59.6 years of age, whereas Group B (58.9 years) had normal Vit D status. The analysis showed a statistically non- significant (p>0.05) difference in average age between the groups. There were 250 patients, with male 43.6% and female 56.4%. Men (63.2%) and women (36.8%) were in Group A. There were 71.4% males and 28.6% females in Group B. We found out the 137(60.6%) significant adverse hospital outcomes (p<0.001) in Group B and had a more significant proportion of patients with diabetes mellitus and who had smoked (p = 0.002 and 0.001, respectively). In a multivariate logistic regression smoking, diabetes, Troponin I and low vitamin showed the significant risk association (p<0.001). Practical Implication: There is still a lack of conclusive evidence on the relationship between vitamin D insufficiency or deficiency and the morbidity and mortality of AMI patients. Until far, there has been no research in Pakistan linking serum vitamin D levels to in-hospital outcomes for patients suffering from acute myocardial infarction. Conclusion: The research shows an association between low Vit D status, adverse outcomes, and clinical parameters after AMI. A low blood Vit D level is independently associated to an increased risk of developing severe clinical outcomes during hospitalization, including death after an AMI. Keyword: Vit D, AMI, Vit D deficiency, low Vit D, Cardiovascular disease

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Section: Introductionsupporting

confidence: 76%

Association of Serum Vit D level with in-Hospital Outcome in Patients with Acute Myocardial Infarction

Din,

Haq,

Adeel

et al. 2023

PJMHS

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“…Thus, their activation counteracts myocardial hypertrophy and hypertension [ 38 ]. In this regard, it is proposed that the activation of VDRs associated with Hsp70 (as a chaperone protein) could favor physiological cardiac remodeling after a myocardial infarction and reduce progression to heart failure [ 39 ].…”

Section: Pleiotropic Effects Of Vitamin D In Inflammatory-based Diseasesmentioning

confidence: 99%

Genomic or Non-Genomic? A Question about the Pleiotropic Roles of Vitamin D in Inflammatory-Based Diseases

et al. 2023

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Vitamin D (vit D) is widely known for its role in calcium metabolism and its importance for the bone system. However, various studies have revealed a myriad of extra-skeletal functions, including cell differentiation and proliferation, antibacterial, antioxidant, immunomodulatory, and anti-inflammatory properties in various cells and tissues. Vit D mediates its function via regulation of gene expression by binding to its receptor (VDR) which is expressed in almost all cells within the body. This review summarizes the pleiotropic effects of vit D, emphasizing its anti-inflammatory effect on different organ systems. It also provides a comprehensive overview of the genetic and epigenetic effects of vit D and VDR on the expression of genes pertaining to immunity and anti-inflammation. We speculate that in the context of inflammation, vit D and its receptor VDR might fulfill their roles as gene regulators through not only direct gene regulation but also through epigenetic mechanisms.

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“…Además, se debe considerar los inhibidores de la enzima convertidora de angiotensina, como captopril o enalapril, o antagonistas del receptor de la angiotensina II, como losartán o valsartán, que están orientados a evitar la remodelación cardiaca que se puede dar a consecuencia de un evento agudo como es el IAM. Probablemente éstos eran todos los medicamentos que formaban parte del esquema terapéutico que recibía [16][17][18][19][20] .…”

Section: Tratamientounclassified

A propósito de Yo, Daniel Blake (2016)

Cordori-Carpio

Chávez-Bautista

Chávez-Escate

et al. 2022

rmc

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Este artículo presenta un análisis sobre la película “I, Daniel Blake” (2016), filme que nos pone en la posición de una persona con una enfermedad crónica degenerativa, mostrándonos el punto de vista de un paciente y su vivencia fuera de los muros del hospital, dentro de un sistema de salud europeo burocratizado y estandarizado que no cubre las necesidades individuales de los enfermos. Se consideran distintos aspectos de interés en este análisis, útiles para la formación universitaria en medicina humana, como lo son; la amenaza que puede significar que el sistema de salud se enfoque en la eficiencia y eficacia de la gestión por encima del bienestar del paciente y la comprensión de relevancia del contexto individual, familiar y comunitario del mismo, evidenciando que el ejercicio y desarrollo de la medicina integral es indispensable para una apropiada atención a los pacientes.

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Implications of the transcription factor WT1 linked to the pathologic cardiac remodeling post-myocardial infarction

Cited by 4 publications

References 26 publications

Association of Serum Vit D level with in-Hospital Outcome in Patients with Acute Myocardial Infarction

Association of Serum Vit D level with in-Hospital Outcome in Patients with Acute Myocardial Infarction

Genomic or Non-Genomic? A Question about the Pleiotropic Roles of Vitamin D in Inflammatory-Based Diseases

A propósito de Yo, Daniel Blake (2016)

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