Implications of salivary protein binding to commensal and pathogenic bacteria

Heo, Seok-Mo; Rühl, Stefan; Scannapieco, Frank A.

doi:10.1016/j.job.2013.06.004

Cited by 14 publications

(11 citation statements)

References 130 publications

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“…Both GspB and Hsa bind to sialic moieties on the platelets (Bensing et al, 2004) and also to salivary glycoproteins such as MG2, salivary agglutinin and secretory IgA (Heo et al, 2013; Takamatsu et al, 2006) suggesting the SRRP glycoproteins also have lectin activities. Extensive studies were carried out to investigate the GspB glycosylation system.…”

Section: Surface Protein Glycosylation In Bacteria Found In the Oral mentioning

confidence: 99%

Insights into bacterial protein glycosylation in human microbiota

Zhu

2015

Sci. China Life Sci.

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The study of human microbiota is an emerging research topic. The past efforts have mainly centered on studying the composition and genomic landscape of bacterial species within the targeted communities. The interaction between bacteria and hosts is the pivotal event in the initiation and progression of infectious diseases. There is a great need to identify and characterize the molecules that mediate the bacteria-host interaction. Bacterial surface exposed proteins play an important role in the bacteria-host interaction. Numerous surface proteins are glycosylated, and the glycosylation is crucial for their function in mediating the bacterial interaction with hosts. Here we present an overview of surface glycoproteins from bacteria that inhabit three major mucosal environments across human body: oral, gut and skin. We describe the important enzymes involved in the process of protein glycosylation, and discuss how the process impacts the bacteria-host interaction. Emerging molecular details underlying glycosylation of bacterial surface proteins may lead to new opportunities for designing anti-infective small molecules, and developing novel vaccines in order to treat or prevent bacterial infection.

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Section: Surface Protein Glycosylation In Bacteria Found In the Oral mentioning

confidence: 99%

Insights into bacterial protein glycosylation in human microbiota

Zhu

2015

Sci. China Life Sci.

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“…1D). Conversely, agglutinins have been described to facilitate bacterial attachment to the tooth surface thereby promoting colonization [72, 94–96]. Agglutinins bound to bacteria may potentially also lead to interspecies attachment during the establishment of oral biofilms [77].…”

Section: Host-derived Innate and Immune-related Compounds In Human Samentioning

confidence: 99%

Glycan recognition at the saliva – oral microbiome interface

Cross

Rühl

2018

Cellular Immunology

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The mouth is a first critical interface where most potentially harmful substances or pathogens contact the host environment. Adaptive and innate immune defense mechanisms are established there to inactivate or eliminate pathogenic microbes that traverse the oral environment on the way to their target organs and tissues. Protein and glycoprotein components of saliva play a particularly important role in modulating the oral microbiota and helping with the clearance of pathogens. It has long been acknowledged that glycobiological and glycoimmunological aspects play a pivotal role in oral host-microbe, microbe-host, and microbe-microbe interactions in the mouth. In this review, we aim to delineate how glycan-mediated host defense mechanisms in the oral cavity support human health. We will describe the role of glycans attached to large molecular size salivary glycoproteins which act as a first line of primordial host defense in the human mouth. We will further discuss how glycan recognition contributes to both colonization and clearance of oral microbes.

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“…Oral salivary flow over a coating is persistent, applies continuous shear forces, and supplies proteins to bacteria, accelerating bacteria metabolism and biofilm growth [96,97].…”

Section: Salivamentioning

confidence: 99%

Bacterial adhesion mechanisms on dental implant surfaces and the influencing factors

Han

Tsoi

Rodrigues

et al. 2016

International Journal of Adhesion and Adhesives

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a b s t r a c tBacterial adhesion on dental implants may cause peri-implant disease including peri-implant mucositis and peri-implantitis. Peri-implantitis may lead to bone resorption and eventually loss of the implant. Therefore, the factors which influence bacterial adhesion are critical and revealed by many studies. The purpose of this review is to summarize the current knowledge of factors influencing the bacteria adhesion, including local factors of implant surface topography, abutment, cement and oral environment factors of saliva and protein. In addition, the corresponding strategies of surface modifications, coatings and challenges for implant materials as prevention and treatment approaches for bacteria adhesion on implant will also be discussed. We expect to give an overall picture of the bacteria adhesion on implant, and provide future perspectives, such as laser therapy, photocatalysis, plasma and bioelectric effect to inspire researchers to explore on this issue.

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Implications of salivary protein binding to commensal and pathogenic bacteria

Cited by 14 publications

References 130 publications

Insights into bacterial protein glycosylation in human microbiota

Insights into bacterial protein glycosylation in human microbiota

Glycan recognition at the saliva – oral microbiome interface

Bacterial adhesion mechanisms on dental implant surfaces and the influencing factors

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