Implications of Methicillin-Resistant Staphylococcus aureus Carriage on Cardiac Surgical Outcomes

Dewan, Krish C.; Dewan, Karan S.; Navale, Suparna M.; Gordon, Steven M.; Svensson, Lars; Gillinov, A. Marc; Rich, Jeffrey B.; Bakaeen, Faisal G.; Soltesz, Edward G.

doi:10.1016/j.athoracsur.2020.03.088

Cited by 2 publications

(4 citation statements)

References 27 publications

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“…30 Neurotoxicity associated with doxorubicin treatment can also be associated with lipid peroxidation. 31 Consistent with earlier observations, doxorubicin treatment increased the lipid peroxidation greater than two-fold. Supplementation of 20 μg/ml of hydroalcoholic extract of Adhatoda vasica significantly restored the peroxidation levels to normal.…”

Section: Discussionsupporting

confidence: 90%

“…35 Moreover, MRSA has poses a great threat during cardiac surgery. 31 A. vasica has been shown to possess a number of bioactive compounds which include vasicine, vasicinone, deoxyvasicine, vasicol, adhatodinine, and vasicinol. The antibacterial activity of the extract could be due to the combined synergistic effect of the compounds rather than the effect of a single compound.…”

Section: Discussionmentioning

confidence: 99%

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Adhatoda vasica Possesses Anti-microbial Activity and Effectively Ameliorates Ischemia Reperfusion Injury Induced by Doxorubicin through Controlling Oxidative Stress

Hershan¹,

Abdulhaq²

2022

Ind. J. Pharm. Edu. Res

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Background and Objectives: Myocardial ischemia is one of the leading causes deaths among cardiac pathological conditions. Doxorubicin belongs to anthracycline class of drug which is effective against a wide variety of neoplasms. However, doxorubicininduced cardiotoxicity limits the clinical utility of the drug. One of the major causes of myocardial ischemia is oxidative stress. Adhatoda vasica have been shown to possess strong anti-inflammatory during ischemia reperfusion injury induced by doxorubicin in zebrafish model. Materials and Methods: Cardiac ischemia was induced in Zebrafish using doxorubicin. Adhatoda vasica was further supplemented and the antioxidants enzymes were analysed. Zebrafish was also infected with MRSA and the anti-microbial activity of A. vasica was analysed. Results: Supplementation with Adhatoda vasica extract to doxorubicin reduces the oxidative stress induced by doxorubicin through improvement of catalase, superoxide dismutase and GSH activities and subsequently reduces lipid peroxidation. Doxorubicin mediated inflammatory response in cardiac tissue is neutralized by supplementation with Adhatoda vasica plant extract and improves the cardiac tissue architecture. A. vasica plant extract is effective against inhibiting the growth of MRSA which has been shown to cause serious complications during cardiac surgery and cardiac prosthetic implantation. A. vasica plant extract causes a dose-dependent suppression of virulence gens such as spA and mecA. Conclusion: Therefore, A. vasica extract may be useful in controlling microbial infections during cardiac complications. In conclusion, the present study indicates that A. vasica can be useful during cardiac complications.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Adhatoda vasica Possesses Anti-microbial Activity and Effectively Ameliorates Ischemia Reperfusion Injury Induced by Doxorubicin through Controlling Oxidative Stress

Hershan¹,

Abdulhaq²

2022

Ind. J. Pharm. Edu. Res

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“…Expert opinion suggests benefit in expansion of coverage to include activity against resistant Gram‐negative pathogens when there is known colonization identified prior to transplantation but this has not been substantiated with robust randomized clinical trials 5 . Pre‐surgical colonization with methicillin‐resistant Staphylococcus aureus has been tied to increased risk of surgical site infection in other procedure types and may benefit from the addition of the targeted therapy such as vancomycin 11 . It is quite common for lung transplant recipients to have known colonization with resistant organisms such as Pseudomonas aeruginosa and it is considered reasonable to include coverage for such organisms when isolated from either recipient or donor in many cases based on the currently available data 12 …”

Section: Peri‐operative Antimicrobial Stewardshipmentioning

confidence: 99%

“…Staphylococcus aureus has been tied to increased risk of surgical site infection in other procedure types and may benefit from the addition of the targeted therapy such as vancomycin. 11 It is quite common for lung transplant recipients to have known colonization with resistant organisms such as Pseudomonas aeruginosa and it is considered reasonable to include coverage for such organisms when isolated from either recipient or donor in many cases based on the currently available data. 12 Another potential factor that may impact antibiotic selection among surgical patients is the history of antibiotic allergy.…”

Section: Surgical Prophylaxis Antibiotic Selectionmentioning

confidence: 99%

Outpatient and peri‐operative antibiotic stewardship in solid organ transplantation

Kinn

İnce

2022

Transplant Infectious Dis

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Background:The consequences of inappropriate antimicrobial use including resistance are increasingly recognized as a global public health threat and many steps have been taken over the last few decades to advance antimicrobial stewardship initiatives with most organ transplant centers currently part of institutions with active antimicrobial stewardship programs.Methods: A review of the literature was conducted and articles were categorized according to the topic and relevance in the judgment of the two authors.Results: A summary review of the currently available literature was created with a focus on periprocedural and outpatient antimicrobial stewardship. Limitations in the data were significant and discussed in the review. Conclusion:The principles of antimicrobial stewardship remain important throughout all phases starting with periprocedural prophylactic antimicrobial selection all the way through to discharge and subsequent healthcare encounters. Despite the broad advances in stewardship initiatives and the rapidly progressing supportive data overall there continue to be significant opportunities for additional research within various special patient populations including recipients of solid organ transplantation (SOT).The recent white paper published in the American Journal of Transplantation called to action the transplant and stewardship communities to have an increased focus and awareness of the issues that antimicrobial overuse can present in the SOT patient population. This is an important step that will hopefully generate more data in this group of patients that arguably faces the greatest vulnerability to the consequences of increased antimicrobial resistance.

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Implications of Methicillin-Resistant Staphylococcus aureus Carriage on Cardiac Surgical Outcomes

Cited by 2 publications

References 27 publications

Adhatoda vasica Possesses Anti-microbial Activity and Effectively Ameliorates Ischemia Reperfusion Injury Induced by Doxorubicin through Controlling Oxidative Stress

Adhatoda vasica Possesses Anti-microbial Activity and Effectively Ameliorates Ischemia Reperfusion Injury Induced by Doxorubicin through Controlling Oxidative Stress

Outpatient and peri‐operative antibiotic stewardship in solid organ transplantation

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