Implications of intrauterine protein malnutrition on prostate growth, maturation and aging

Rinaldi, Jaqueline de Carvalho; Justulin, Luís Antônio; Lacorte, Lívia M.; Sarobo, Carolina; Bôer, Patrícia Aline; Scarano, Wellerson Rodrigo; Felisbino, Sérgio Luís

doi:10.1016/j.lfs.2013.02.007

Cited by 31 publications

(51 citation statements)

References 54 publications

(71 reference statements)

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“…This phenomenon is called "catch-up growth." It has been observed in many protocols involving fetal programming (Zambrano et al, 2005(Zambrano et al, , 2006Wu et al, 2012;Rinaldi et al, 2013;Pinho et al, 2014) and can be extended to the prostatic microenvironment (Rinaldi et al, 2013). Our results showed an increased cell proliferation index in the LZ and HZ groups on PND115 and a reduction in PAR4 expression, a sign of apoptosis in the prostate (Boghaert et al, 1997).…”

Section: Discussionsupporting

confidence: 69%

“…The recovery of body and organ weight is well described in fetal programming environments due to protein restriction (Wu et al, ), where the animals exposed to a hostile nutritional environment during gestation present an accentuated growth when exposed to a “normal” nutritional environment. This phenomenon is called “catch‐up growth.” It has been observed in many protocols involving fetal programming (Zambrano et al, , ; Wu et al, ; Rinaldi et al, ; Pinho et al, ) and can be extended to the prostatic microenvironment (Rinaldi et al, ). Our results showed an increased cell proliferation index in the LZ and HZ groups on PND115 and a reduction in PAR4 expression, a sign of apoptosis in the prostate (Boghaert et al, ).…”

Section: Discussionmentioning

confidence: 96%

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Impact of maternal and postnatal zinc dietary status on the prostate of pubescent and adult rats

Camora

Silva

Santos

et al. 2017

Cell Biology International

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Zinc is important for cell physiology and alteration of its levels during development can modulate a series of biological events. The aim of this study was to investigate whether dietary zinc deficiency or supplementation during morphogenesis and early postnatal development could interfere in prostate maturation. Pregnant rats were exposed to a standard diet (NZ:35 mg Zn/kg chow), low-zinc diet (LZ:3 mg of Zn/kg chow) and zinc-supplemented diet (HZ:180 mg/Kg chow) from gestational day 10 (GD10) through postnatal day 21 (PND21). After weaning, male offspring were divided into three groups that were submitted to the same food conditions as their mothers until PND53. The animals were euthanized at PND53 and PND115. The ventral prostate was removed, weighed and its fragments were subjected to histological, western blot and zymography analysis. PND53: body and prostate weight were lower in LZ compared to NZ; the epithelial compartment was reduced while the stromal compartment was increased in LZ compared to NZ; there was an increase in the amount of collagen and reduction in AR and SIRT1 expression in LZ compared to NZ. PND115: body weight was lower in LZ compared to NZ and prostate weight was similar among the groups; peripheral physiological hyperplasia was observed, as well as an increased epithelial proliferation index and reduced PAR4 expression in LZ and HZ compared to NZ. Zinc deficiency during prostate morphogenesis and differentiation is potentially harmful to its morphology, however, by restoring the standard dietary environment, the gland responds to the new microenvironment independent of the previous dietary condition.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 96%

Impact of maternal and postnatal zinc dietary status on the prostate of pubescent and adult rats

Camora

Silva

Santos

et al. 2017

Cell Biology International

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“…Food consumption was determined using weekly measurements of the difference in the amount of pellet food provided at the beginning of the interval from that remaining at the end of the interval (Rinaldi et al 2013). Food consumption was determined using weekly measurements of the difference in the amount of pellet food provided at the beginning of the interval from that remaining at the end of the interval (Rinaldi et al 2013).…”

Section: Animals and Experimental Proceduresmentioning

confidence: 99%

Protective effect of γ‐tocopherol‐enriched diet on N‐methyl‐N‐nitrosourea‐induced epithelial dysplasia in rat ventral prostate

Sanches

Santos

Carvalho

et al. 2013

Int J Experimental Path

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Despite recent advances in understanding the biological basis of prostate cancer (PCa), the management of this disease remains a challenge. Chemoprotective agents have been used to protect against or eradicate prostate malignancies. Here, we investigated the protective effect of γ-tocopherol on N-methyl-N-nitrosourea (MNU)-induced epithelial dysplasia in the rat ventral prostate (VP). Thirty-two male Wistar rats were divided into four groups (n = 8): control (CT): healthy control animals fed a standard diet; control+γ-tocopherol (CT+γT): healthy control animals without intervention fed a γ-tocopherol-enriched diet (20 mg/kg); N-methyl-N-nitrosourea (MNU): rats that received a single dose of MNU (30 mg/kg) plus testosterone propionate (100 mg/kg) and were fed a standard diet; and MNU+γ-tocopherol (MNU+γT): rats that received the same treatment of MNU plus testosterone and were fed with a γ-tocopherol-enriched diet (20 mg/kg). After 4 months, the VPs were excised to evaluate morphology, cell proliferation and apoptosis, as well as cyclooxygenase-2 (Cox-2), glutathione-S-transferase-pi (GST-pi) and androgen receptor (AR) protein expression, and matrix metalloproteinase-9 (MMP-9) activity. An increase in the incidence of epithelial dysplasias, such as stratified epithelial hyperplasia and squamous metaplasia, in the MNU group was accompanied by augmented cell proliferation, GST-pi and Cox-2 immunoexpression and pro-MMP-9 activity. Stromal thickening and inflammatory foci were also observed. The administration of a γ-tocopherol-enriched diet significantly attenuated the adverse effects of MNU in the VP. The incidence of epithelial dysplasia decreased, along with the cell proliferation index, GST-pi and Cox-2 immunoexpression. The gelatinolytic activity of pro-MMP-9 returned to the levels observed for the CT group. These results suggest that γ-tocopherol acts as a protective agent against MNU-induced prostatic disorders in the rat ventral prostate.

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“…Protein‐restricted maternal nutrition during rat gestation or lactation causes a reduction in body and prostate weight . Previous reports demonstrate that this condition decreases estrogen levels , but there is no consensus regarding increased or decreased testosterone levels found in the literature. However, apparently protein restriction during gestation/lactation promotes an imbalance in sexual hormones.…”

Section: Introductionmentioning

confidence: 99%

“…There is wide evidence that an alteration in sex steroid signaling induced by exposure to androgen, estrogen, or endocrine-disrupting chemicals (EDC) in intra-uterine and neonatal life may impact prostate development and alter the susceptibility to prostate disease later in life [20][21][22][23][24][25]. However, the consequences of altered intra-uterine nutrition on prostate maturation and health remain elusive, particularly as regards excessive dietary fat [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Differential ontogenetic exposure to obesogenic environment induces hyperproliferative status and nuclear receptors imbalance in the rat prostate at adulthood

et al. 2016

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Implications of intrauterine protein malnutrition on prostate growth, maturation and aging

Abstract: Our findings show that MPM delays prostate development, growth and maturation until adulthood, probably as a result of low testosterone stimuli. The higher incidence of cellular dysplasia and prostatitis suggests that MPM increases prostate susceptibility to diseases with aging.

Cited by 31 publications

References 54 publications

Impact of maternal and postnatal zinc dietary status on the prostate of pubescent and adult rats

Impact of maternal and postnatal zinc dietary status on the prostate of pubescent and adult rats

Protective effect of γ‐tocopherol‐enriched diet on N‐methyl‐N‐nitrosourea‐induced epithelial dysplasia in rat ventral prostate

Differential ontogenetic exposure to obesogenic environment induces hyperproliferative status and nuclear receptors imbalance in the rat prostate at adulthood

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