Implications of immunomodulatory interleukins for the hyperimmunoglobulinemia of Sjögren’s syndrome

Girón-González, José A.; Baturone, R; Soto, Marı́a José; Márquez, M.; Macías, Inmaculada; de, M Montes; Medina, Francisco J.; Chozas, Nicolás; Garcia-Perez, S

doi:10.1016/j.cellimm.2009.05.013

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…These findings suggest that IL-4 promotes B-cell proliferation in this model (Nguyen and Peck, 2009). IL-4 has also been implicated in the pathogenesis of the hypergammaglobulinemia that develops in SS (Giron-Gonzalez et al, 2009). …”

Section: 1 Th2mentioning

confidence: 99%

“…Interestingly, increased Th1/Th2 ratios was observed in more severe SS cases (Ajjan et al, 1998; Giron-Gonzalez et al, 2009; Konttinen et al, 1999), whereas increased Th-2 response correlated with milder SS (Kang et al, 2011; Mitsias et al, 2002; Pertovaara et al, 2006; van Woerkom et al, 2005). IFN-γ expression has been evaluated in minor salivary glands of human SS patients, as well as lacrimal and submandibular (SMG) gland biopsies in animal models.…”

Section: 1 Th1 Pathwaymentioning

confidence: 99%

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T helper cytokines in dry eye disease

Pflugfelder

Corrales

Paiva

2013

Experimental Eye Research

133

117

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Dry eye is an inflammatory disease that results from activation of innate inflammatory pathways in resident ocular surface cells, as well as cytokines produced by recruited T helper (Th) cells. Cytokines produced by the infiltrating Th cells alter the normal cytokine balance on the ocular surface and cause ocular surface epithelial pathology. Changes in levels of Th cytokines on the ocular surface have been measured in dry eye and the biological effects of these cytokines have been documented in experimental culture and mouse model systems. The Th2 cytokine IL-13 has a homeostatic role in promoting goblet cell differentiation. In contrast, The Th1 cytokine IFN-γ antagonizes IL-13 and promotes apoptosis and squamous metaplasia of the ocular surface epithelia. The Th17 cytokine, IL-17 promotes corneal epithelial barrier disruption. The ocular surface epithelium expresses receptors to all of these Th cytokines. Therapies that maintain normal IL-13 signaling, or suppress IFN- γ and IL-17 have potential for treating the ocular surface disease of dry eye.

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Section: 1 Th2mentioning

confidence: 99%

Section: 1 Th1 Pathwaymentioning

confidence: 99%

T helper cytokines in dry eye disease

Pflugfelder

Corrales

Paiva

2013

Experimental Eye Research

133

117

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“…In patients with SjS salivary IL-10 levels were found to be significantly increased as compared to healthy controls and was also shown to correlate with symptom severity for xerophthalmia and xerostomia [81]. Additionally, significant increases in systemic levels of IL-10 (and IL-4) have been demonstrated to correlate with SjS disease [82,83]. The supposition that there may be a genetic predisposition to SjS led to the evaluation IL-10 promoter polymorphisms.…”

Section: Transgenic Modelsmentioning

confidence: 99%

The value of animal models to study immunopathology of primary human Sjögren's syndrome symptoms

Donate

Voigt

Nguyen

2014

Expert Review of Clinical Immunology

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Sjögren’s syndrome (SjS) is a complex chronic autoimmune disease of multifactorial etiology that results in eventual loss of secretory function in the exocrine glands. The challenges towards finding a therapeutic prevention or treatment for SjS are due primarily to a lack of understanding in the pathophysiological and clinical progression of the disease. In order to circumnavigate this problem, there is a need for appropriate animal models that resemble the major phenotypes of human SjS and deliver a clear underlying biological or molecular mechanism capable of defining various aspects for the disease. Here, we present an overview of SjS mouse models that are providing insight into the autoimmune process of SjS and advance our focus on potential diagnostic and therapeutic targets.

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“…Its levels are raised in many autoimmune diseases and it can activate both T and B-cells [91]. A number of studies have identified raised IL-6 levels in the serum and salivary glands of patients with PSS [76,[92][93][94][95][96][97][98][99][100][101]. Whether there is a direct correlation between serum IL-6 or soluble IL-6 receptor levels and clinical features such as fatigue or health-related quality of life in pSS is a matter of ongoing debate [102][103][104].…”

Section: Anti-il-6 Directed Therapiesmentioning

confidence: 99%