Implications of genomics in oral health

Govindraju, Poornima; Chandra, Poornima

doi:10.15713/ins.jcri.65

Search citation statements

Order By: Relevance

Paper Sections

Select...

Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Majority of the OSCC arise from premalignant lesions like oral submucosal fibrosis (OSMF) and leukoplakia [4]. OSMF is a potential premalignant condition of the oral cavity with around 7.6% malignant transformation rate [5].…”

Section: Introductionmentioning

confidence: 99%

Serum Survivin in Oral Submucosal Fibrosis and Squamous Cell Carcinoma

Thota

Aggarwal

Chirom

et al. 2020

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Survivin, an inhibitor of apoptosis protein is a biomarker of significance in prognostication of many malignancies. In the current study we investigated the serum survivin levels in patients with oral submucosal fibrosis (OSMF) and squamous cell carcinoma (OSCC). Serum was isolated from, peripheral blood collected of clinically and histopathologically confirmed OSMF and OSCC patients. Circulating level of survivin was measured in patients and control subjects by ELISA and analyzed further using Kruskal-Wallis test and two-sample Wilcoxon rank-sum (Mann-Whitney) test. Serum Survivin levels were significantly reduced in the OSCC group as compared to the control group. No significant correlation was noted between the serum survivin level and various clinicopathological characteristics of OSCC and OSMF patients. Our study suggests that free, wild form of circulating survivin probably has no role in predicting the prognosis of oral cancer or the malignant transformation potential of oral submucosal fibrosis.

show abstract

Section: Introductionmentioning

confidence: 99%