Implications of Frailty in Copd Exacerbations

Almanzar, Aimee; Alonso, Armando Cabrera; Jafri, Asma; Saad, Hector Vazquez; Hernández, F.J. López; Perez, Livasky Concepcion; Lisigurski, Miriam Zylberglait; Ferrer, Gustavo

doi:10.1016/j.chest.2019.08.476

Cited by 2 publications

(1 citation statement)

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“…Particularly in more severe stages of COPD, frailty has negative impacts on mobility and daily functioning [80]. It increases the risk of acute exacerbations of COPD (AECOPD) [50,74,[80][81][82][83] and may relate to higher levels of C-reactive protein, which is, in turn, associated with increased exacerbations, poorer lung function and mortality [84,85]. Moreover, COPD exacerbations in people with frailty carry an increased (6.3-fold) risk of requiring mechanical ventilation compared to people without frailty [81], and the presence of frailty during COPD exacerbations has been suggested to associate with increased risk of readmission and/or mortality [86].…”

Section: Copdmentioning

confidence: 99%

European Respiratory Society statement on frailty in adults with chronic lung disease

et al. 2023

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Frailty is a complex, multidimensional syndrome characterised by a loss of physiological reserves that increases a person's susceptibility to adverse health outcomes. Most knowledge regarding frailty originates from geriatric medicine, however, awareness of its importance as a treatable trait for people with chronic respiratory disease (including asthma, COPD and interstitial lung disease) is emerging. A clearer understanding of frailty and its impact in chronic respiratory disease is a pre-requisite to optimise clinical management in the future. This unmet need underpins the rationale for undertaking the present work.This European Respiratory Society Statement synthesises current evidence and clinical insights from international experts and people affected by chronic respiratory conditions regarding frailty in adults with chronic respiratory disease. The scope includes coverage of frailty within international respiratory guidelines, prevalence and risk factors, review of clinical management options (including comprehensive geriatric care, rehabilitation, nutrition, pharmacological and psychological therapies), and identification of evidence gaps to inform future priority areas of research. Frailty is under-represented in international respiratory guidelines, despite being common and related to increased hospitalisation and mortality. Validated screening instruments can detect frailty to prompt comprehensive assessment and personalised clinical management. Clinical trials targeting people with chronic respiratory disease and frailty are needed.

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