Implications of faecal egg count variation when using the Kato-Katz method to assess Schistosoma mansoni infections

Barreto, Maurício Lima; Smith, D. H.; Sleigh, Adrian

doi:10.1016/0035-9203(90)90037-f

Cited by 56 publications

(33 citation statements)

References 3 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Here we report 2 years post-treatment and confirm that although some subjects of the same cohort still had high levels of antibodies against both recombinant antigens, levels of antibody isotypes against recombinant PMY and TEG did not correlate with epidemiological susceptibility to S. juponicum re-infection. Re-infection was determined by repeat stool examination at the end-point of study (BARRETO et al, 1990;ROSS et al, 1998~). In addition, we were unable to induce protection against S. juponicum in recent experiments with mice and buffaloes vaccinated with the same Escherichiu coli-produced recombinant TEG despite the production ofhigh levels of antibody to this protein (LI et al, 2000b).…”

Section: Discussionmentioning

confidence: 99%

Human susceptibility to Schistosoma japonicum in China correlates with antibody isotypes to native antigens

Li¹,

Sleigh²,

Ross³

et al. 2001

Transactions of the Royal Society of Tropical Medicine and Hygi

View full text Add to dashboard Cite

Antibody isotypic responses (IgE, IgA, IgGl, IgG2, IgG3 and IgG4) to Schistosoma japonicum antigensadult worm (AWA), soluble egg (SEA) and the recombinant proteins TEG (22.6-kDa tegumental antigen, $22) and PMY (paramyosin, Sj97)-were measured (in 1998) in a cohort of 179 Chinese subjects 2 years post-treatment. Subjects in the highest intensity re-infection group (>lOO eggs per gram faeces) had significantly higher levels of IgGl and IgG4 against AWA. Analysis of IgG4IIgE ratios for AWA and SEA linked IgG4 excess to re-infection and IgE excess to non-re-infection. Two years after chemotherapeutic cure, 29 subjects, who were re-infected or never infected but highly water-exposed, were classified as epidemiologically susceptible (n = 15) or epidemiologically insusceptible to infection (n = 14). IgG4 levels against native antigens (AWA and SEA) were higher in susceptibles and IgE levels were higher in insusceptibles but antibody responses to the recombinant proteins (PMY and TEG) showed no clear pattern or difference between susceptibility groups. These and earlier findings provide evidence that immunity develops against schistosomiasis japonica in China and that susceptibility/resistance correlates with antibody isotypes against native schistosome antigens.

show abstract

Section: Discussionmentioning

confidence: 99%

Human susceptibility to Schistosoma japonicum in China correlates with antibody isotypes to native antigens

Li¹,

Sleigh²,

Ross³

et al. 2001

Transactions of the Royal Society of Tropical Medicine and Hygi

View full text Add to dashboard Cite

show abstract

“…When two slides each of the second, third and fourth sample were examined, this rate increased from 15.4-26.4% and 28.9%, respectively. Considering the results obtained, the analysis of three faecal samples seems to be the best choice because the variation in the number of S. mansoni eggs discharged in the faeces on different days is accounted for using this approach (Barreto et al 1990, Engels et al 1996, Kongs et al 2001, Enk et al 2008. However, this approach will certainly present important logistical problems for surveys performed on a large scale, neutralising all of the operational advantages of this method.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of two coproscopic techniques for the diagnosis of schistosomiasis in a low-transmission area in the state of Minas Gerais, Brazil

Siqueira¹,

Coelho²,

Oliveira³

et al. 2011

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

“…Thus, it is impractical to initiate such a strategy at the national level for routine schistosomiasis control programs. Repeated fecal smear examinations, usually from a single stool specimen, are useful for boosting the accuracy of diagnosis for field research (11,153).…”

Section: Parasitological Examinationmentioning

confidence: 99%

Schistosomiasis in the People's Republic of China: Prospects and Challenges for the 21st Century

et al. 2001

View full text Add to dashboard Cite

Schistosomiasis japonica is a serious communicable disease and a major disease risk for more than 30 million people living in the tropical and subtropical zones of China. Infection remains a major public health concern despite 45 years of intensive control efforts. It is estimated that 865,000 people and 100,250 bovines are today infected in the provinces where the disease is endemic, and its transmission continues. Unlike the other schistosome species known to infect humans, the oriental schistosome, Schistosoma japonicum, is a true zoonotic organism, with a range of mammalian reservoirs, making control efforts extremely difficult. Clinical features of schistosomiasis range from fever, headache, and lethargy to severe fibro-obstructive pathology leading to portal hypertension, ascites, and hepatosplenomegaly, which can cause premature death. Infected children are stunted and have cognitive defects impairing memory and learning ability. Current control programs are heavily based on community chemotherapy with a single dose of the drug praziquantel, but vaccines (for use in bovines and humans) in combination with other control strategies are needed to make elimination of the disease possible. In this article, we provide an overview of the biology, epidemiology, clinical features, and prospects for control of oriental schistosomiasis in the People's Republic of China

show abstract

Implications of faecal egg count variation when using the Kato-Katz method to assess Schistosoma mansoni infections

Cited by 56 publications

References 3 publications

Human susceptibility to Schistosoma japonicum in China correlates with antibody isotypes to native antigens

Human susceptibility to Schistosoma japonicum in China correlates with antibody isotypes to native antigens

Evaluation of two coproscopic techniques for the diagnosis of schistosomiasis in a low-transmission area in the state of Minas Gerais, Brazil

Schistosomiasis in the People's Republic of China: Prospects and Challenges for the 21st Century

Contact Info

Product

Resources

About