Implications of Evolving and Emerging Pharmacokinetic-Pharmacodynamic Research for Triazoles and Echinocandins

Comparative efficacy and safety of systemic antifungal agents for candidemia: a systematic review with network meta-analysis and multicriteria acceptability analyses

“…Scientific literature shows that, for true treatment effectiveness, with reduced mycological load as an outcome, the different doses of echinocandins must reach the AUC:MIC threshold of 3000 [36]. This is probably not achieved with the current concentrations of anidulafungin used in the studies included in this review.…”

“…Anidulafungin showed an inferior response compared to the other drugs of the class with probabilities of leading to overall response of under 45%. This may be justified by the difference in the ratio between the area under the curve and minimum inhibitory concentration (AUC:MIC) and volume of distribution of these drugs [34][35][36].…”