Implications of disease-modifying therapies for multiple sclerosis on immune cells and response to COVID-19 vaccination
Valeria Orrù,
Valentina Serra,
Michele Marongiu
et al.
Abstract:IntroductionDisease-modifying therapies (DMTs) have been shown to improve disease outcomes in multiple sclerosis (MS) patients. They may also impair the immune response to vaccines, including the SARS-CoV-2 vaccine. However, available data on both the intrinsic immune effects of DMTs and their influence on cellular response to the SARS-CoV-2 vaccine are still incomplete.MethodsHere, we evaluated the immune cell effects of 3 DMTs on the response to mRNA SARS-CoV-2 vaccination by comparing MS patients treated wi… Show more
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