Implications of differences in expression of sarcosine metabolism-related proteins according to the molecular subtype of breast cancer

Yoon, Ja Kyung; Kim, Do Hee; Koo, Ja Seung

doi:10.1186/1479-5876-12-149

Cited by 19 publications

(15 citation statements)

References 29 publications

(37 reference statements)

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“…As it was evidenced, sarcosine increased amount also stimulates the SARDH expression. Although there is a lack of direct evidence of linkage between SARDH and PCa aggressiveness, Yoon and coworkers demonstrated that the expression of SARDH is associated with shorter overall survival of subjects suffering from luminal A type breast cancer [25]. Although here we report obvious effects of sarcosine treatment on its pathway in vivo , further analysis of metabolic activities of sarcosine associated enzymes might be done to shed more light into this phenomenon.…”

Section: Discussionmentioning

confidence: 61%

Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer

et al. 2016

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The effects of sarcosine on the processes driving prostate cancer (PCa) development remain still unclear. Herein, we show that a supplementation of metastatic PCa cells (androgen independent PC-3 and androgen dependent LNCaP) with sarcosine stimulates cells proliferation in vitro. Similar stimulatory effects were observed also in PCa murine xenografts, in which sarcosine treatment induced a tumor growth and significantly reduced weight of treated mice (p < 0.05). Determination of sarcosine metabolism-related amino acids and enzymes within tumor mass revealed significantly increased glycine, serine and sarcosine concentrations after treatment accompanied with the increased amount of sarcosine dehydrogenase. In both tumor types, dimethylglycine and glycine-N-methyltransferase were affected slightly, only. To identify the effects of sarcosine treatment on the expression of genes involved in any aspect of cancer development, we further investigated expression profiles of excised tumors using cDNA electrochemical microarray followed by validation using the semi-quantitative PCR. We found 25 differentially expressed genes in PC-3, 32 in LNCaP tumors and 18 overlapping genes. Bioinformatical processing revealed strong sarcosine-related induction of genes involved particularly in a cell cycle progression. Our exploratory study demonstrates that sarcosine stimulates PCa metastatic cells irrespectively of androgen dependence. Overall, the obtained data provides valuable information towards understanding the role of sarcosine in PCa progression and adds another piece of puzzle into a picture of sarcosine oncometabolic potential.

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Section: Discussionmentioning

confidence: 61%

Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer

et al. 2016

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“…Although sarcosine is mainly known as a prostate cancer‐associated metabolite, it has also been implicated in a subset of metastatic breast cancer cases. High expression of GNMT and low expression of SARDH, collectively referred to as ‘high sarcosine type,’ is associated with the human epidermal growth factor receptor 2 positive subtype of breast cancer and negatively correlated with disease‐free survival of breast cancer patients . Sarcosine metabolism in breast cancer also appears to be differentially regulated according to the metastatic site, with bone and lung metastases tending to show a ‘high sarcosine type.’ Although information on the importance of sarcosine in other cancer types is currently scarce, it has been shown to play a role in metastatic prostate and breast cancers, the two cancer types with second‐highest incidence rates in men and women, respectively.…”

Section: Amino Acidsmentioning

confidence: 99%

Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyond

Teoh

Lunt

2017

WIREs Mechanisms of Disease

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Metabolic changes accompany tumor progression and metastatic dissemination of cancer cells. Yet, until recently, metabolism has received little attention in the study of cancer metastasis. Cancer cells undergo significant metabolic rewiring as they acquire metastatic traits and adapt to survive in multiple environments with varying nutrient availability, oxygen concentrations, and extracellular signals. Therefore, to effectively treat metastatic cancer, it is important to understand the metabolic strategies adopted by cancer cells during the metastatic process. Here, we focus on the metabolic pathways known to play a role in cancer metastasis, including glycolysis, the pentose phosphate pathway, tricarboxylic acid cycle, oxidative phosphorylation, amino acid metabolism, and fatty acid metabolism. Recent studies have uncovered roles for these pathways in cellular events that promote metastasis, including reactive oxygen species-mediated signaling, epigenetic regulation, and interaction with the extracellular matrix. We also discuss the metabolic interplay between immune cells and cancer cells supporting metastasis. Finally, we highlight the current limitations of our knowledge on this topic, and present future directions for the field. WIREs Syst Biol Med 2018, 10:e1406. doi: 10.1002/wsbm.1406 This article is categorized under: Biological Mechanisms > Metabolism.

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“…Metabolomic analyses indicate that androgen supplementation results in elevated amino acid metabolism and increased methylation activity in PCa cells [114,115]. Interestingly, in breast cancer, the expression of sarcosine-related enzymes has been shown to vary according to cancer subtype [115]. A parallel with GNMT could be established with studies conducted on Nicotinamide N -methyltransferase (NNMT) [116].…”

Section: Androgen Signaling Regulates the Expression Of Enzymes Inmentioning

confidence: 99%

One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling

Corbin

Ruiz-Echevarría

2016

IJMS

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Cancer cell metabolism differs significantly from the metabolism of non-transformed cells. This altered metabolic reprogramming mediates changes in the uptake and use of nutrients that permit high rates of proliferation, growth, and survival. The androgen receptor (AR) plays an essential role in the establishment and progression of prostate cancer (PCa), and in the metabolic adaptation that takes place during this progression. In its role as a transcription factor, the AR directly affects the expression of several effectors and regulators of essential catabolic and biosynthetic pathways. Indirectly, as a modulator of the one-carbon metabolism, the AR can affect epigenetic processes, DNA metabolism, and redox balance, all of which are important factors in tumorigenesis. In this review, we focus on the role of AR-signaling on one-carbon metabolism in tumorigenesis. Clinical implications of one-carbon metabolism and AR-targeted therapies for PCa are discussed in this context.

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Implications of differences in expression of sarcosine metabolism-related proteins according to the molecular subtype of breast cancer

Cited by 19 publications

References 29 publications

Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer

Sarcosine Up-Regulates Expression of Genes Involved in Cell Cycle Progression of Metastatic Models of Prostate Cancer

Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyond

One-Carbon Metabolism in Prostate Cancer: The Role of Androgen Signaling

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