Implications of Crosstalk between Exosome-Mediated Ferroptosis and Diseases for Pathogenesis and Treatment

Zhou, Zixuan; You, Benshuai; Ji, Chenfeng; Zhang, Leilei; Wu, Feng; Qian, Hui

doi:10.3390/cells12020311

Cited by 14 publications

(5 citation statements)

References 105 publications

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“…In the I/R myocardial injury model, it was shown that exosomes derived from hUCB-MSCs and loaded with exosomal miR-23a-3p inhibited ferroptosis by regulating iron metabolism independent of the GPX4 pathway [233]. The role of exosomes in ferroptosis-related pathogenic mechanisms in various diseases is described in detail in this review [234]. Figure 5 shows the scheme of hepatocyte protection from ferroptosis due to MSC and MSC derivatives.…”

Section: Anti-ferroptosis and Anti-pyroptosis Effects Of Mscmentioning

confidence: 99%

The Crosstalk between Mesenchymal Stromal/Stem Cells and Hepatocytes in Homeostasis and under Stress

Kholodenko,

Yarygin

2023

IJMS

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Liver diseases, characterized by high morbidity and mortality, represent a substantial medical problem globally. The current therapeutic approaches are mainly aimed at reducing symptoms and slowing down the progression of the diseases. Organ transplantation remains the only effective treatment method in cases of severe liver pathology. In this regard, the development of new effective approaches aimed at stimulating liver regeneration, both by activation of the organ’s own resources or by different therapeutic agents that trigger regeneration, does not cease to be relevant. To date, many systematic reviews and meta-analyses have been published confirming the effectiveness of mesenchymal stromal cell (MSC) transplantation in the treatment of liver diseases of various severities and etiologies. However, despite the successful use of MSCs in clinical practice and the promising therapeutic results in animal models of liver diseases, the mechanisms of their protective and regenerative action remain poorly understood. Specifically, data about the molecular agents produced by these cells and mediating their therapeutic action are fragmentary and often contradictory. Since MSCs or MSC-like cells are found in all tissues and organs, it is likely that many key intercellular interactions within the tissue niches are dependent on MSCs. In this context, it is essential to understand the mechanisms underlying communication between MSCs and differentiated parenchymal cells of each particular tissue. This is important both from the perspective of basic science and for the development of therapeutic approaches involving the modulation of the activity of resident MSCs. With regard to the liver, the research is concentrated on the intercommunication between MSCs and hepatocytes under normal conditions and during the development of the pathological process. The goals of this review were to identify the key factors mediating the crosstalk between MSCs and hepatocytes and determine the possible mechanisms of interaction of the two cell types under normal and stressful conditions. The analysis of the hepatocyte–MSC interaction showed that MSCs carry out chaperone-like functions, including the synthesis of the supportive extracellular matrix proteins; prevention of apoptosis, pyroptosis, and ferroptosis; support of regeneration; elimination of lipotoxicity and ER stress; promotion of antioxidant effects; and donation of mitochondria. The underlying mechanisms suggest very close interdependence, including even direct cytoplasm and organelle exchange.

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Section: Anti-ferroptosis and Anti-pyroptosis Effects Of Mscmentioning

confidence: 99%

The Crosstalk between Mesenchymal Stromal/Stem Cells and Hepatocytes in Homeostasis and under Stress

Kholodenko,

Yarygin

2023

IJMS

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“…91 Circulating exosomes can mediate cell-to-cell communication and organ cross talk, serving as carriers of functional proteins and nucleic acids from parental cells. 92 Cancer-associated fibroblasts (CAFs) secrete various bioactive substances, including exosomes. For example, CAFs Obesity is strongly linked to the poor prognosis in advanced colorectal cancer patients, with unclear mechanisms.…”

Section: Ferroptosismentioning

confidence: 99%

“…Exosomes have also shown their potential in ferroptosis‐based cancer treatment, validated in multiple types of tumors 91 . Circulating exosomes can mediate cell‐to‐cell communication and organ cross talk, serving as carriers of functional proteins and nucleic acids from parental cells 92 . Cancer‐associated fibroblasts (CAFs) secrete various bioactive substances, including exosomes.…”

Section: Exosomes In Different Types Of Pcdmentioning

confidence: 99%

The role of exosomes in cancer‐related programmed cell death

Li,

Jing,

et al. 2023

Immunological Reviews

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SummaryCancer arises from the growth and division of uncontrolled erroneous cells. Programmed cell death (PCD), or regulated cell death (RCD), includes natural processes that eliminate damaged or abnormal cells. Dysregulation of PCD is a hallmark of cancer, as cancer cells often evade cell death and continue to proliferate. Exosomes nanoscale extracellular vesicles secreted by different types of cells carrying a variety of molecules, including nucleic acids, proteins, and lipids, to have indispensable role in the communication between cells, and can influence various cellular processes, including PCD. Exosomes have been shown to modulate PCD in cancer cells by transferring pro‐ or antideath molecules to neighboring cells. Additionally, exosomes can facilitate the spread of PCD to surrounding cancer cells, making them promising in the treatment of various cancers. The exosomes' diagnostic potential in cancer is also an active area of research. Exosomes can be isolated from a wide range of bodily fluids and tissues, such as blood and urine, and can provide a noninvasive way to monitor cancer progression and treatment response. Furthermore, exosomes have also been employed as a delivery system for therapeutic agents. By engineering exosomes to carry drugs or other therapeutic molecules, they can be targeted specifically to cancer cells, reducing toxicity to healthy tissues. Here, we discussed exosomes in the diagnosis and prevention of cancers, tumor immunotherapy, and drug delivery, as well as in different types of PCD.

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“…Notably, exosome and ferroptosis may interplay with each other [ 10 , 11 , 12 , 13 , 14 , 15 ]. Exosomes may enhance or suppress ferroptosis in several diseases and cancers [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…The inhibition of ferroptosis may be triggered via exosome-mediated regulation that acts on ferroptosis signaling [ 10 ]. Exosomes may deliver biomolecules to recipient cells and, in turn, regulate ferroptosis-modulating signaling and response [ 11 , 12 ]. For example, breast cancerous exosomes suppress migration mediated by ferroptosis [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Ferroptosis-Regulated Natural Products and miRNAs and Their Potential Targeting to Ferroptosis and Exosome Biogenesis

Chuang,

Yen,

Chien

et al. 2024

IJMS

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Ferroptosis, which comprises iron-dependent cell death, is crucial in cancer and non-cancer treatments. Exosomes, the extracellular vesicles, may deliver biomolecules to regulate disease progression. The interplay between ferroptosis and exosomes may modulate cancer development but is rarely investigated in natural product treatments and their modulating miRNAs. This review focuses on the ferroptosis-modulating effects of natural products and miRNAs concerning their participation in ferroptosis and exosome biogenesis (secretion and assembly)-related targets in cancer and non-cancer cells. Natural products and miRNAs with ferroptosis-modulating effects were retrieved and organized. Next, a literature search established the connection of a panel of ferroptosis-modulating genes to these ferroptosis-associated natural products. Moreover, ferroptosis-associated miRNAs were inputted into the miRNA database (miRDB) to bioinformatically search the potential targets for the modulation of ferroptosis and exosome biogenesis. Finally, the literature search provided a connection between ferroptosis-modulating miRNAs and natural products. Consequently, the connections from ferroptosis–miRNA–exosome biogenesis to natural product-based anticancer treatments are well-organized. This review sheds light on the research directions for integrating miRNAs and exosome biogenesis into the ferroptosis-modulating therapeutic effects of natural products on cancer and non-cancer diseases.

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Implications of Crosstalk between Exosome-Mediated Ferroptosis and Diseases for Pathogenesis and Treatment

Cited by 14 publications

References 105 publications

The Crosstalk between Mesenchymal Stromal/Stem Cells and Hepatocytes in Homeostasis and under Stress

The Crosstalk between Mesenchymal Stromal/Stem Cells and Hepatocytes in Homeostasis and under Stress

The role of exosomes in cancer‐related programmed cell death

Ferroptosis-Regulated Natural Products and miRNAs and Their Potential Targeting to Ferroptosis and Exosome Biogenesis

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