Implications of circulating irisin and Fabp4 levels in patients with polycystic ovary syndrome

Abalı, Remzi; Yüksel, İlkbal Temel; Yüksel, Mehmet Aytaç; Bulut, Berk; İmamoğlu, Metehan; Emirdar, Volkan; Ünal, Fehmi; Güzel, Savaş; Çelik, Cem

doi:10.3109/01443615.2016.1174200

Cited by 28 publications

(35 citation statements)

References 31 publications

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“…Consistent with our data, Abali et al found a negative correlation between LH and serum levels of irisin in adult PCOS and control women. In line with the hormonal data, the degree of hirsutism was also negatively correlated with irisin.…”

Section: Discussionsupporting

confidence: 93%

“…The skeletal muscle is a crucial regulatory site of insulin resistance through uptake of the majority of glucose . Serum irisin was positively correlated with fasting glucose, insulin and HOMA‐IR and negatively associated with QUICKI and also predicted fasting glucose in the overall study sample (PCOS adolescents and controls).…”

Section: Discussionmentioning

confidence: 93%

“…Few studies have examined serum irisin levels in adult women with PCOS; however, data comparing serum irisin concentrations in adult PCOS women with control women have been inconsistent. Four studies demonstrated significantly elevated irisin levels in patients with PCOS compared to those of control women, whereas others showed significantly lower mean serum irisin concentrations in women with PCOS than control subjects or nonsignificant differences . Body mass index (BMI) may be a confounding factor in these studies, as irisin, a general indicator of body fat mass, has been found to be positively correlated with BMI in adult women with or without PCOS and across a wide range of BMI …”

Section: Introductionmentioning

confidence: 99%

“…4 Current knowledge about the function of the hormone irisin in biological systems is limited. 6 Few studies 5,[7][8][9][10][11][12][13] have examined serum irisin levels in adult women with PCOS; however, data comparing serum irisin concentrations in adult PCOS women with control women have been inconsistent. Four studies demonstrated significantly elevated irisin levels in patients with PCOS compared to those of control women, 5,7,9,13 whereas others showed significantly lower mean serum irisin concentrations in women with PCOS than control subjects 8 or nonsignificant differences.…”

Section: Introductionmentioning

confidence: 99%

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Serum irisin concentrations in lean adolescents with polycystic ovary syndrome

Bacopoulou

Αθανασόπουλος

Efthymiou

et al. 2018

Clinical Endocrinology

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Serum irisin concentrations in lean adolescents with polycystic ovary syndrome

Bacopoulou

Αθανασόπουλος

Efthymiou

et al. 2018

Clinical Endocrinology

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“…At baseline values irisin seems to increase or not different in insulin resistance models such as polycystic ovary syndrome (PCOS) as reported by recent papers [30, 31]. …”

Section: Discussionmentioning

confidence: 72%

Irisin: A Potential Link between Physical Exercise and Metabolism—An Observational Study in Differently Trained Subjects, from Elite Athletes to Sedentary People

Benedini

Dozio

Invernizzi

et al. 2017

Journal of Diabetes Research

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We compared irisin levels among groups of differently trained healthy individuals to explore the role of irisin as a physiological linker between exercise and metabolic health. Irisin and biochemical parameters of glucose and lipid metabolism were assessed in 70 healthy volunteers stratified for sport performance level into four groups: (1) 20 elite athletes of national level, (2) 20 subelite athletes of local level, (3) 20 recreational athletes, and (4) 10 sedentary subjects. All biochemical parameters were within the ranges of normality. Fasting glucose, HOMA-IR, and total cholesterol levels were inversely related to the degree of physical activity. HbA1c was higher in elite athletes compared to all the other groups (p < 0.01). A U-shaped relation between free fatty acids and the degree of physical activity was observed. All groups showed similar plasma irisin levels. After correction for the degree of insulin resistance (irisin/HOMA-IR), elite athletes showed higher levels compared to sedentary and recreational subjects (p < 0.01 and p < 0.05, resp.). In addition, the number of metabolic parameters correlated with irisin increased at increasing the training status. Our study suggests a correlation between sport performance, insulin sensitivity, and irisin levels. Irisin may be one potential mediator of the beneficial effects of exercise on metabolic profile.

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Effects of intracerebroventricular administration of irisin on the hypothalamus–pituitary–gonadal axis in male rats

Tekin

Beytur

Erden

et al. 2018

Journal Cellular Physiology

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Irisin is a product of fibronectin type III domain‐containing protein 5 (FNDC5) and plays an important role in energy homeostasis. In this study, we aimed to determine effects of intracerebroventricular administration of irisin on the hypothalamus–pituitary–gonadal axis by molecular, biochemical, and morphological findings. Fourty male Wistar‐Albino rats were used and divided into four groups including control, sham (vehicle), 10, and 100 nM irisin infused groups (n = 10). Hypothalamic gonadotropin releasing hormone (GnRH) level and serum luteinizing hormone (LH), follicle‐stimulating hormone (FSH), and testosterone levels were determined. Testicular tissue histology and spermiogram analysis were also performed. Both irisin concentrations significantly reduced hypothalamic GnRH messenger RNA (mRNA) and protein levels (p < 0.05). It was found that serum LH, FSH, and testosterone levels and Sertoli and Leydig cell numbers were decreased by irisin administration (p < 0.05). In addition, irisin administration reduced sperm density and mobility (p < 0.05). However, it did not cause any change in testicular and epididymis weights and tubular diameter. Our results reveal that irisin can play a role in the central regulation of reproductive behavior and also reduces testosterone levels by suppressing LH and FSH secretion. These results suggest that the discovery of irisin receptor antagonists may be beneficial in the treatment of infertility.

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Implications of circulating irisin and Fabp4 levels in patients with polycystic ovary syndrome

Cited by 28 publications

References 31 publications

Serum irisin concentrations in lean adolescents with polycystic ovary syndrome

Serum irisin concentrations in lean adolescents with polycystic ovary syndrome

Irisin: A Potential Link between Physical Exercise and Metabolism—An Observational Study in Differently Trained Subjects, from Elite Athletes to Sedentary People

Effects of intracerebroventricular administration of irisin on the hypothalamus–pituitary–gonadal axis in male rats

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