Implications of circadian gene expression in kidney, liver and the effects of fasting on pharmacogenomic studies

Kita, Yasuhiro; Shiozawa, Masahide; Wu, Jin; Majewski, R. R.; Besharse, Joseph C.; Greene, Andrew S.; Jacob, Howard J.

doi:10.1097/00008571-200201000-00008

Cited by 135 publications

(91 citation statements)

References 44 publications

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“…Interestingly, fasting alters circadian gene expression in various tissues. 43) Also, streptozotocin-induced diabetic rat showed phase shift and/or upswing of clock genes expressions. 12) Therefore, plasma level of insulin and glucose may be the candidates of modulator of circadian gene expression in adipose tissue.…”

Section: Discussionmentioning

confidence: 98%

Characteristics of Circadian Gene Expressions in Mice White Adipose Tissue and 3T3-L1 Adipocytes

Aoyagi

Shimba

Tezuka

2005

JOURNAL OF HEALTH SCIENCE

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Most, if not all, of physiological and behavioral processes exhibit circadian rhythms. Recently, molecular clocks similar to those operating in the suprachiasmatic nucleus (SCN) neurons have been found in several peripheral tissues. Among peripheral tissues, several recent studies have revealed that white adipose tissues secrete a number of biologically active molecules such as leptin, resistin, adiponectin, etc. Importantly, the levels of these cytokine-like molecules are associated with development of lifestyle-related diseases such as diabetic mellitus, cardiovascular diseases, and obesity. In this study, we attempted to characterize circadian gene expression in adipose tissue. Here, we show that the expression of several clock genes exhibits daily oscillation in mice white adipocytes. Circadian expression of adipocytes-related genes such as peroxisome proliferator-activated receptor (PPAR) γ2 was also observed. Interestingly, expression pattern of some clock genes in adipocytes is distinct from that in stromal-vascular fractions containing preadipocytes. In addition to these in vivo studies, we demonstrated that serum-or dexamethasone-shock induced the cyclic gene expression of clock genes in cultured adipocytes. Consequently, we are led to conclude that adipocytes contain the machineries necessary for circadian oscillation similar to that found in SCN. We then examined that whether the pharmacological effects of PPARγ2 ligand depend on the time of administration. Consist with its receptor levels, the pharmacological effects of PPARγ ligand administered during a dark period were more efficient than those during a light period in mice. These results suggest that chronotherapy targeted for adipocyte functions could be effective in improving of the symptoms of hyperlipidemia and other related diseases.

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Section: Discussionmentioning

confidence: 98%

Characteristics of Circadian Gene Expressions in Mice White Adipose Tissue and 3T3-L1 Adipocytes

Aoyagi

Shimba

Tezuka

2005

JOURNAL OF HEALTH SCIENCE

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“…Each study has employed a different plat form, data analysis methods, and screened different numbers of genes. In general, it appears that about 10 % of the genes are circadianly expressed in the liver, heart, and kidneys (Akhtar et al, 2002;Kita et al, 2002;Panda et al, 2002;Storch et al, 2002;Ueda et al, 2002). Interestingly, in the fibroblasts it has been reported that fewer than 100 genes (or about 2% of the genes present in these cells) are rhythmically expressed (Duffield et al, 2002;Grundschober et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

“…In the recent years, the DNA microarray technique has been successfully used to study circadian gene expression in the SCN, liver, heart, kidney, and fibroblasts (Grundschober et al, 2001;Akhtar et al, 2002;Duffield et al, 2002;Kita et al, 2002;Panda et al, 2002;Storch et al, 2002;Ueda et al, 2002). The picture that is emerging from these studies indicates that in each tissue or organ a certain number of genes (approximately 2-10 %) are under circadian control.…”

Section: Introductionmentioning

confidence: 99%

Analysis of daily and circadian gene expression in the rat pineal gland

Fukuhara¹,

Tosini²

2008

Neuroscience Research

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The mammalian pineal gland is an important component of the circadian system. In the present study, we examined the expression of roughly 8000 genes in the rat pineal gland as a function of time of day under light-dark (LD) cycles and in constant dark (DD) using oligo DNA microarray technique. We identified 47 and 13 genes that showed higher levels at night and day, respectively, under LD. The same patterns of expression were also observed in DD. About half of the genes that peaked at night have a known biological function, i.e., transcription factors and proteins that are involved in signaling cascades, whereas 14 are expressed sequence tags and 8 have an unknown biological function. Twelve of the genes that are up-regulated at night were also up-regulated after 1 h NE stimulation, thus suggesting that the expression of these genes is controlled by adrenergic mechanisms. Of the 13 genes that were up-regulated in the daytime, 6 coded for proteins that are involved in intracellular signaling pathways. The results obtained with microarray analysis were well correlated with data obtained using real time quantitative RT-PCR. The present results provide new materials to dissect and understand the pineal physiology.

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“…For example, E box enhancer regulates gene expression of a variety of factors that include a neuropeptide arginine vasopressin (Jin et al , 1999), a secreted protein prokineticin 2 (Cheng et al , 2002), a serine protease inhibitor plasminogen activator inhibitor-1 (Maemura et al , 2000), a transcription factor c-Myc (Fu et al , 2002), and the Cdc2 kinase WEE1 . Recent studies using DNA microarray technology identified a large number of rhythmically expressed genes (Grundschober et al , 2001;Akhtar et al , 2002;Duffield et al , 2002;Humphries et al , 2002;Kita et al , 2002;Panda et al , 2002a;Storch et al , 2002;Ueda et al , 2002;Oishi et al , 2003). Some of these genes may be regulated directly by the transcription factors involved in the oscillatory loops through the upstream ciselements, such as E box, REV-ERB α /ROR response element, and DBP-binding site (Ueda et al , 2002).…”

Section: Oscillation Of Mammalian Circadian Clockmentioning

confidence: 99%