2022
DOI: 10.3390/clinpract12060108
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Implications of Cellular Immaturity in Necrosis and Microvascularization in Glioblastomas IDH-Wild-Type

Abstract: Necrosis and increased microvascular density in glioblastoma IDH-wild-type are the consequence of both hypoxia and cellular immaturity. Our study aimed to identify the main clinical-imaging and morphogenetic risk factors associated with tumor necrosis and microvascular in the prognosis of patient survival. We performed a retrospective study (10 years) in which we identified 39 cases. We used IDH1, Ki-67 and Nestin immunomarkers, as well as CDKN2A by FISH. The data were analyzed using SPSS Statistics. The clini… Show more

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Cited by 3 publications
(2 citation statements)
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References 62 publications
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“…However, the intra-and interobserver variability of Ki-67, which is dependent on the heterogeneity of the tumor and the area under examination, discourages it from being validated as a prognostic factor [41]. In our study, the agreement coefficient between the conventional method and the AI method indicates an excellent level of reliability (ICC1-0.970, ICC2-0.990).…”
Section: Discussionmentioning
confidence: 54%
“…However, the intra-and interobserver variability of Ki-67, which is dependent on the heterogeneity of the tumor and the area under examination, discourages it from being validated as a prognostic factor [41]. In our study, the agreement coefficient between the conventional method and the AI method indicates an excellent level of reliability (ICC1-0.970, ICC2-0.990).…”
Section: Discussionmentioning
confidence: 54%
“…Several active efforts to re-evaluate existing or investigate new anti-GBM agents are ongoing, and our results expand the possibilities of investigating other combinatorial therapies. Another important aspect of GBM treatment includes the fact that chemotherapeutic regimens are largely non-selective and cytotoxic in nature, and despite all the efforts, almost all patients experience tumor progression, with nearly universal mortality and a median survival of less than 15 months, depending on several risk factors [ 60 ]. There is a need to optimize the balance between effectiveness and toxicity, and the use of small EVs may help to reduce the amount of drug given to a patient in order to reach the same effect.…”
Section: Discussionmentioning
confidence: 99%