Implications of C1q/TNF-related protein-3 (CTRP-3) and progranulin in patients with acute coronary syndrome and stable angina pectoris

Abstract

BackgroundC1q/TNF-related protein-3 (CTRP-3), an adiponectin paralog, and progranulin were recently identified as novel adipokines which may link obesity with glucose dysregulation and subclinical inflammation. We analyzed the relationship between CTRP-3, progranulin and coronary artery disease (CAD) in Korean men and women.MethodsCirculating CTRP-3 and progranulin levels were examined in 362 Korean adults with acute coronary syndrome (ACS, n = 69), stable angina pectoris (SAP, n = 85), and control subjects (n = 208) along with various kinds of cardiometabolic risk factors.ResultsCTRP-3 concentrations were significantly decreased in patients with ACS or SAP compared to control subjects (P <0.001, respectively), whereas progranulin and adiponectin levels were similar. Correlation analysis adjusted for age and gender exhibited that CTRP-3 levels showed significant negative relationship with glucose (r = -0.110, P = 0.041) and high sensitive C-reactive protein (hsCRP) levels (r = -0.159, P = 0.005), and positive relationship with HDL-cholesterol (r = 0.122, P = 0.025) and adiponectin levels (r = 0.194, P <0.001). In a multivariate logistic regression analysis, the odds ratio for CAD risk was 5.14 (95% CI, 1.83-14.42) in the second, and 9.04 (95% CI, 2.81-29.14) in the first tertile of CTRP-3 levels compared to third tertile after adjusting for other cardiometabolic risk variables.ConclusionsPatients with ACS or SAP had significantly lower circulating CTRP-3 concentrations compared to control subjects, although progranulin levels were not different. These results suggest the possibility that CTRP-3 might be useful for assessing the risk of CAD.Trial registration(Clinical trials No.: NCT01594710)

Association of C1q/TNF-Related Protein-3 (CTRP3) and CTRP13 Serum Levels with Coronary Artery Disease in Subjects with and without Type 2 Diabetes Mellitus

“…Also, Peterson et al have shown an immunomodulatory role for CTRP3 in systemic and chronic inflammation associated with insulin resistance and obesity, but no role in antagonizing LPS induced inflammation in mice model [31]. A more recent study reported a decrease in CTRP3 serum levels in stable and unstable angina pectoris patients [32]. In line with this, we showed that serum concentration of CTRP3 is lower in CAD patients with and without T2DM.…”

“…Multivariate logistic regression shows the independent association between CTRP3 serum levels and the presence of CAD in non-T2DM subject and also in all participants. A previous study in patients without diabetes showed significant association of circulating CTRP3 with CAD [32]. In addition to non-T2DM, present study included T2DM patients.…”

CTRP3 attenuates post-infarct cardiac fibrosis by targeting Smad3 activation and inhibiting myofibroblast differentiation

“…It has been found that CTRP3 concentration shows a significant correlation with cardiometabolic risk factors, including waist circumference, diastolic blood pressure, fasting glucose, triglyceride, total cholesterol, and adiponectin levels [28]. Moreover, plasma CTRP3 level is significantly decreased in patients with acute coronary syndrome and stable angina pectoris [29]. More importantly, a recent study provides evidence that plasma CTRP3 level and CTRP3 mRNA expression in adipose tissue are decreased in a mouse MI model [17].…”

Plasma C1q/TNF-Related Protein-9 Levels Are Associated with Atherosclerosis in Patients with Type 2 Diabetes without Renal Dysfunction

“…First, we examined only CTRP9 based on its high similarity to adiponectin and the abundance in experimental evidence of its vascular effects [10–14]. Since CTRP1 [39] and CTRP3 [34, 40] were also indicated to be linked to atherosclerosis, the other members of the CTRP family need to be examined in the future. Second, because this was a cross-sectional study, a causal relationship between CTRP9 and carotid atherosclerosis could not be confirmed.…”