Implications for management of ovarian cancer in a transgender man: Impact of androgens and androgen receptor status

Aubrey, Christa; Saad, Nathalie; Köbel, Martin; Mattatall, Fiona; Nelson, Gregg; Glaze, Sarah

doi:10.1016/j.ygyno.2021.02.019

Cited by 7 publications

(6 citation statements)

References 41 publications

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“…Aubrey et al [ 69 ] published a similar case report about a 36-year-old transgender man diagnosed with stage IIA ovarian endometrium cancer who underwent a bilateral salpingo-oophorectomy followed by six cycles of chemotherapy. This patient also was using hormone therapy, which was discontinued after surgery[ 69 ].…”

Section: Resultsmentioning

confidence: 99%

Cancer screening and management in the transgender population: Review of literature and special considerations for gender affirmation surgery

Panichella,

Araya,

Nannapaneni

et al. 2023

World J Clin Oncol

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It is now well established that the biology of cancer is influenced by not only malignant cells but also other components of the tumour microenvironment. Chronic inflammation and fibrosis have long been postulated to be involved in carcinogenesis. Chronic inflammation can promote tumorigenesis via growth factor/cytokine-mediated cellular proliferation, apoptotic resistance, immunosuppression; and free-radical-induced oxidative deoxyribonucleic acid damage. Fibrosis could cause a perturbation in the dynamics of the tumour microenvironment, potentially damaging the genome surveillance machinery of normal epithelial cells. In this review, we will provide an in-depth discussion of various diseases characterised by inflammation and fibrosis that have been associated with an increased risk of malignancy. In particular, we will present a comprehensive overview of the impact of alterations in stromal composition on tumorigenesis, induced as a consequence of inflammation and/or fibrosis. Strategies including the application of various therapeutic agents with stromal manipulation potential and targeted cancer screening for certain inflammatory diseases which can reduce the risk of cancer will also be discussed.

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Section: Resultsmentioning

confidence: 99%

Cancer screening and management in the transgender population: Review of literature and special considerations for gender affirmation surgery

Panichella,

Araya,

Nannapaneni

et al. 2023

World J Clin Oncol

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“…HSPA5 [87] and AR (androgen receptor) [100] have been demonstrated to enhance obesity. Altered expression of HSPA5 [293], AR (androgen receptor) [309] and TCF4 [320] were associated with progression of cancer. Altered expression of HSPA5 [376], RIN3 [350] and DISC1 [398] were found to be substantially related to neurological and psychological problems.…”

Section: Discussionmentioning

confidence: 99%

“…HSPA5 [87], F2RL1 [58], AR (androgen receptor) [100], SOCS1 [63], RUNX2 [542] and ESR1 [543] were an important participant in obesity. HSPA5 [293], AR (androgen receptor) [309], TCF4 [320], SOCS1 [255], PTN (pleiotrophin) [251], hsa-mir-21-3p [544], SOX2 [545], GATA2 [546], RUNX2 [547], DROSHA [548], ESR1 [549] and PAX3 [550] have been discovered to be involved in the cancer. HSPA5 [376], RIN3 [350], PTN (pleiotrophin) [339], DISC1 [398], hsa-mir-378a-5p [551], hsa-mir-5010-3p [552] and hsa-mir-21-3p [553] are believed to be associated with neurological and psychological problems.…”

Section: Discussionmentioning

confidence: 99%

The Identification of Key Genes and Biological Pathways in Polycystic Ovary Syndrome and its Complications by Next Generation Squancing (NGS) and Bioinformatics Analysis

Vastrad¹,

Vastrad²

2023

Preprint

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Polycystic ovary syndrome (PCOS) is is associated with infertility, obesity, insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, hypertension, cardiovascular problems, neurological and psychological problems and cancer. The specific mechanism of PCOS and its complications remains unclear. The aim of this study was to apply a bioinformatics approach to reveal related pathways or genes involved in the development of PCOS and its complications. The next generation squancing (NGS) datset GSE199225 was downloaded from the gene expression omnibus (GEO) database. Differentially expressed gene (DEG) analysis was performed using DESeq2. The g:Profiler was utilized to analyze the functional enrichment, gene ontology (GO) and REACTOME pathway of the differentially expressed genes. A protein-protein interaction (PPI) network was constructed and module analysis was performed using HiPPIE and cytoscape. The miRNA-hub gene regulatory network and TF-hub gene regulatory network were also constructed for research. The expression of the hub genes was validated using receiver operating characteristic (ROC) curve analysis. We have identified 957 DEGs in total, including 478 up regulated genes and 479 down regulated gene. GO and REACTOME illustrated that DEGs in PCOS were significantly enriched in regulation of molecular function, developmental process, interferon signaling and platelet activation, signaling and aggregation. Finally, through analyzing the PPI network, modules, miRNA-hub gene regulatory network and TF-hub gene regulatory network, we screened hub genes HSPA5, PLK1, RIN3, DBN1, CCDC85B, DISC1, AR, MTUS2, LYN and TCF4 by the Cytoscape software. This study uses a series of bioinformatics technologies to obtain hug genes and key pathways related to PCOS and its complications. These analysis results provide us with novel ideas for finding biomarkers and treatment methods for PCOS and its complications.

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“…These factors have been shown to play key roles in access to and utilization of various aspects of clinical care in previous studies, with impacts on survival [34][35][36][37][38][39][40][41][42][43]. Ovarian cancer care within other underserved communities, such as trans men (and other members of the LGBTQ2S+ community), has been understudied [44,45]; further, significant barriers to optimal care have been identified, such as discrimination by care providers and a lack of knowledge about trans-specific healthcare needs and their bodies.…”

Section: Discussionmentioning

confidence: 99%

Understanding the Experience of Canadian Women Living with Ovarian Cancer through the Every Woman StudyTM

2022

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The Every Woman StudyTM: Canadian Edition is the most comprehensive study to date exploring patient-reported experiences of ovarian cancer (OC) on a national scale. An online survey conducted in Fall 2020 included individuals diagnosed with OC in Canada, reporting responses from 557 women from 11 Canadian provinces/territories. Median age at diagnosis was 54 (11–80), 61% were diagnosed between 2016–2020, 59% were stage III/IV and all subtypes of OC were represented. Overall, 23% had a family history of OC, 75% had genetic testing and 19% reported having a BRCA1/2 mutation. Most (87%) had symptoms prior to diagnosis. A timely diagnosis of OC (≤3 months from first presentation with symptoms) was predicted by age (>50) or abdominal pain/persistent bloating as the primary symptom. Predictors of an acute diagnosis (<1 month) included region, ER/urgent care doctor as first healthcare provider or stage III/IV disease. Regional differences in genetic testing, treatments and clinical trial participation were also noted. Respondents cited substantial physical, emotional, practical and financial impacts of an OC diagnosis. Our national survey has revealed differences in the pathway to diagnosis and post-diagnostic care among Canadian women with OC, with region, initial healthcare provider, specific symptoms and age playing key roles. We have identified many opportunities to improve both clinical and supportive care of OC patients across the country.

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Implications for management of ovarian cancer in a transgender man: Impact of androgens and androgen receptor status

Cited by 7 publications

References 41 publications

Cancer screening and management in the transgender population: Review of literature and special considerations for gender affirmation surgery

Cancer screening and management in the transgender population: Review of literature and special considerations for gender affirmation surgery

The Identification of Key Genes and Biological Pathways in Polycystic Ovary Syndrome and its Complications by Next Generation Squancing (NGS) and Bioinformatics Analysis

Understanding the Experience of Canadian Women Living with Ovarian Cancer through the Every Woman StudyTM

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