Implication of Melanopsin and Trigeminal Neural Pathways in Blue Light Photosensitivity in vivo

Marek, Veronika; Reboussin, Élodie; Dégardin-Chicaud, Julie; Charbonnier, Angéline; Domínguez-López, Alfredo; Villette, Thierry; Denoyer, Alexandre; Baudouin, Christophe; Goazigo, Annabelle Réaux‐Le; Mélik-Parsadaniantz, Stéphane

doi:10.3389/fnins.2019.00497

Cited by 27 publications

(31 citation statements)

References 66 publications

(103 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another possible explanation for the presence of persistent corneal damage after cataract surgery may be involved altered corneal mechanosensitivity mediating intrinsically photosensitive retinal ganglion cells (ipRGCs) [24,25]. With the existence of melanopsin, ipRGCs respond to light in the absence of rod and cone photoreceptor input.…”

Section: Discussionmentioning

confidence: 99%

“…With the existence of melanopsin, ipRGCs respond to light in the absence of rod and cone photoreceptor input. [26] IpRGCs project in the ciliary marginal zone [27] and iris [28], mediating innate light aversion into tissues in the anterior segments that receive trigeminal innervation [25]. Although melanopsin absorbs blue light with a peak absorption of approximately 460 to 480 nm [29,30], previous studies have reported a significant increase in blue light transmission and subsequent ipRGC activation in both blue-light blocking IOLs and clear IOLs after cataract surgery [31].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Persistently Worsened Tear Break-up Time and Keratitis in Unilateral Pseudophakic Eyes after a Long Postoperative Period

et al. 2020

View full text Add to dashboard Cite

Dry eye disease may develop and persist after cataract surgery; however, unilateral cases have not been fully documented. This cross-sectional, observational study was conducted in five eye clinics in Japan. A total of 1023 outpatients were initially enrolled, and 89 unilateral pseudophakic subjects with 1+ year of follow-up after uncomplicated cataract surgery were included. The tear break-up times (TBUTs) and keratoconjunctival staining results were compared between phakic and pseudophakic eyes. The mean age of the patients was 69.3 ± 10.4 years (32 men, 36.0%), and the mean postoperative period was 4.6 ± 4.4 (1–20) years. For the ophthalmic parameters, the TBUTs were 4.4 ± 1.9 and 3.8 ± 1.9 s (p < 0.001), the keratoconjunctival staining scores were 0.11 ± 0.38 and 0.22 ± 0.56 (p = 0.02), the spherical equivalents were −1.27 ± 2.51 and −0.99 ± 1.45 D (p = 0.21), the astigmatic errors were 0.79 ± 0.66 and 0.78 ± 0.58 D (p = 0.80), and the intraocular pressures were 13.6 ± 2.9 and 13.5 ± 2.6 mmHg (p = 0.62) for the phakic and pseudophakic eyes, respectively. The corneal status was significantly worse in the pseudophakic eyes than in the contralateral phakic eyes, even after more than one year after implant surgery. The present results suggested that long-term ocular surface problems should be examined further since they may not originate only from surgery or postoperative ocular surface diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Persistently Worsened Tear Break-up Time and Keratitis in Unilateral Pseudophakic Eyes after a Long Postoperative Period

et al. 2020

View full text Add to dashboard Cite

show abstract

“…These findings collectively indicate that the afferent arm of the light-induced lacrimation reflex pathway is melanopsin-mediated and that it functions normally in participants with migraine. Although it is plausible that the newly identified melanopsin-containing trigeminal fibers [ 36 – 38 ] may contribute to the light-induced lacrimation we observed, their contribution was eliminated or minimized during our experiment because the ocular surface was anesthetized with the use of topical proparacaine, which acts as an antagonist to voltage-gated sodium channels.…”

Section: Discussionmentioning

confidence: 99%

Investigation of light-induced lacrimation and pupillary responses in episodic migraine

et al. 2020

View full text Add to dashboard Cite

The purpose of this pilot study was to investigate the light-induced pupillary and lacrimation responses mediated by intrinsically photosensitive retinal ganglion cells (ipRGCs) in migraine. Ten participants with episodic migraine and normal tear production, as well as eleven visually normal controls participated in this study. Following an initial baseline trial (no light flash), participants received seven incremental and alternating red and blue light flashes. Pupillometry recording of the left eye and a 1-min anesthetized Schirmer’s test of the right eye (using 0.5% proparacaine) were performed simultaneously. Intrinsic and extrinsic ipRGC photoactivities did not differ between migraine participants and controls across all intensities and wavelengths. Migraine participants, however, had significantly lower lacrimation than controls following the highest blue intensity. A positive correlation was found between melanopsin-driven post-illumination pupillary responses and lacrimation following blue stimulation in both groups. Our results show that participants with self-reported photophobia have normal ipRGC-driven responses, suggesting that photophobia and pupillary function may be mediated by distinct ipRGC circuits. The positive correlation between melanopsin-driven pupillary responses and light-induced lacrimation suggests the afferent arm of the light-induced lacrimation reflex is melanopsin-mediated and functions normally in migraine. Lastly, the reduced melanopsin-mediated lacrimation at the highest stimulus suggests the efferent arm of the lacrimation reflex is attenuated under certain conditions, which may be a harbinger of dry eye in migraine.

show abstract

“…In rodents, bright light activates the trigeminal ganglion and trigeminal nucleus caudalis [73][74][75] . Human studies suggest an interaction of the peripheral trigeminal system and light-mediated pathways, as noxious trigeminal stimulation lowers the visual discomfort threshold, and light stimulation lowers trigeminal pain thresholds 11,76 .…”

Section: The Neural Locus Of Amplificationmentioning

confidence: 99%

Selective amplification of ipRGC signals accounts for interictal photophobia in migraine

McAdams

Kaiser

Igdalova

et al. 2020

Preprint

View full text Add to dashboard Cite

Second only to headache, photophobia is the most debilitating symptom reported by people with migraine. While the melanopsin-containing, intrinsically photosensitive retinal ganglion cells (ipRGCs) are thought to play a role, how cone and melanopsin signals are integrated in this pathway to produce visual discomfort is poorly understood.We studied 60 people: 20 without headache and 20 each with interictal photophobia from migraine with or without aura. Participants viewed pulses of spectral change that selectively targeted melanopsin, the cones, or both, and rated the degree of visual discomfort produced by these stimuli while we also recorded pupil responses.We examined the data within a model that describes how cone and melanopsin signals are weighted and combined at the level of the retina, and how this combined signal is transformed into a rating of discomfort or pupil response. Our results indicate that people with migraine do not differ from headache-free controls in the manner in which melanopsin and cone signals are combined. Instead, people with migraine demonstrate an amplification of integrated ipRGC signals for discomfort.This effect of migraine is selective for ratings of visual discomfort, in that an amplification of pupil responses was not seen in the migraine group, nor were group differences found in surveys of other behaviors putatively linked to ipRGC function (chronotype, seasonal sensitivity, presence of a photic sneeze reflex).By revealing a dissociation in the amplification of discomfort versus pupil response, our findings suggest a post-retinal alteration in processing of ipRGC signals for photophobia in migraine. SignificanceThe melanopsin-containing, intrinsically photosensitive retinal ganglion cells (ipRGCs) may contribute to photophobia in migraine. We measured visual discomfort and pupil responses to cone and melanopsin stimulation-the photoreceptor inputs to the ipRGCs-in people with and without migraine. We find that people with migraine do not differ from those without headaches in how cone and melanopsin signals are weighted and combined to produce visual discomfort.Instead, migraine is associated with an amplification of ipRGC signals for discomfort. This effect of migraine upon ipRGC signals is limited to photophobia, as we did not find an enhancement of pupil responses or a change in other behaviors linked to ipRGC function. Our findings suggest a post-retinal amplification of ipRGC signals for photophobia in migraine.

show abstract

Implication of Melanopsin and Trigeminal Neural Pathways in Blue Light Photosensitivity in vivo

Cited by 27 publications

References 66 publications

Persistently Worsened Tear Break-up Time and Keratitis in Unilateral Pseudophakic Eyes after a Long Postoperative Period

Persistently Worsened Tear Break-up Time and Keratitis in Unilateral Pseudophakic Eyes after a Long Postoperative Period

Investigation of light-induced lacrimation and pupillary responses in episodic migraine

Selective amplification of ipRGC signals accounts for interictal photophobia in migraine

Contact Info

Product

Resources

About