Implication of lncRNA ZBED3-AS1 downregulation in acquired resistance to Temozolomide and glycolysis in glioblastoma

Dong, Jiajun; Peng, Yilong; Zhong, Minggu; Xie, Zhengyuan; Jiang, Zongyuan; Wang, Kang; Wu, Yi Long

doi:10.1016/j.ejphar.2022.175444

Cited by 10 publications

(3 citation statements)

References 38 publications

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“…This reinforces the potential of this angiogenic and pro-tumoral vascularization gene set itself as a prognosis biomarker. In addition, a worse prognosis correlated with the overexpression of 16 of our genes has also been demonstrated in several studies in the literature [ [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] ]. Consequently, our gene set findings provide validation for the notion that higher tumor vascularity corresponds to a more unfavorable prognosis, reinforcing the importance of investigating tumor vascularity.…”

Section: Discussionsupporting

confidence: 63%

“…*** IL1B 1.785 0.00216 Cytokine Integrine binding IL1R binding Protein domain specific binding 0.15 High expression of IL1B in GB patients have a significant impact for low OS [ 36 ]. *** THBD 1.486 0.00289 Calcium ion binding Transmembrane signaling receptor 0.041* THBD increased TMZ resistance and glycolysis in TMZ-resistant cells [ 37 ]. NCF4 1.158 0.00514 PI3P binding Superoxide-generating NADPH oxidase activator activity 0.12 Diminished NCF4 RNA expression is significantly associated with increased glioma survival [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…Some of them, including CCL4, IL10, and THBD, have well-studied mechanisms that contribute to tumor growth promotion. The release of CCL4 aids in tumor invasion [ 30 ], IL10 plays a role in immunosuppression [ 31 ], and THBD contributes to enhanced resistance to TMZ [ 37 ]. This reinforces the potential of this angiogenic and pro-tumoral vascularization gene set itself as a prognosis biomarker.…”

Section: Discussionmentioning

confidence: 99%

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The prognostic relevance of a gene expression signature in MRI-defined highly vascularized glioblastoma

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Heliyon

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Section: Discussionsupporting

confidence: 63%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The prognostic relevance of a gene expression signature in MRI-defined highly vascularized glioblastoma

Montosa-i-Micó,

Álvarez-Torres,

Burgos-Panadero

et al. 2024

Heliyon

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lncRNAs: New players of cancer drug resistance via targeting ABC transporters

Ebrahimnezhad,

Asl,

Rezaie

et al. 2024

IUBMB Life

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Cancer drug resistance poses a significant obstacle to successful chemotherapy, primarily driven by the activity of ATP‐binding cassette (ABC) transporters, which actively efflux chemotherapeutic agents from cancer cells, reducing their intracellular concentrations and therapeutic efficacy. Recent studies have highlighted the pivotal role of long noncoding RNAs (lncRNAs) in regulating this resistance, positioning them as crucial modulators of ABC transporter function. lncRNAs, once considered transcriptional noise, are now recognized for their complex regulatory capabilities at various cellular levels, including chromatin modification, transcription, and post‐transcriptional processing. This review synthesizes current research demonstrating how lncRNAs influence cancer drug resistance by modulating the expression and activity of ABC transporters. lncRNAs can act as molecular sponges, sequestering microRNAs that would otherwise downregulate ABC transporter genes. Additionally, they can alter the epigenetic landscape of these genes, affecting their transcriptional activity. Mechanistic insights reveal that lncRNAs contribute to the activity of ABC transporters, thereby altering the efflux of chemotherapeutic drugs and promoting drug resistance. Understanding these interactions provides a new perspective on the molecular basis of chemoresistance, emphasizing the regulatory network of lncRNAs and ABC transporters. This knowledge not only deepens our understanding of the biological mechanisms underlying drug resistance but also suggests novel therapeutic strategies. In conclusion, the intricate interplay between lncRNAs and ABC transporters is crucial for developing innovative solutions to combat cancer drug resistance, underscoring the importance of continued research in this field.

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The pathogenesis mechanism and potential clinical value of lncRNA in gliomas

Liu,

Yuan,

Fan

et al. 2024

Discov Onc

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Glioma is the most common malignant tumor in the central nervous system, and its unique pathogenesis often leads to poor treatment outcomes and prognosis. In 2021, the World Health Organization (WHO) divided gliomas into five categories based on their histological characteristics and molecular changes. Non-coding RNA is a type of RNA that does not encode proteins but can exert biological functions at the RNA level, and long non-coding RNA (lncRNA) is a type of non-coding RNA with a length exceeding 200 nt. It is controlled by various transcription factors and plays an indispensable role in the regulatory processes in various cells. Numerous studies have confirmed that the dysregulation of lncRNA is critical in the pathogenesis, progression, and malignancy of gliomas. Therefore, this article reviews the proliferation, apoptosis, invasion, migration, angiogenesis, immune regulation, glycolysis, stemness, and drug resistance changes caused by the dysregulation of lncRNA in gliomas, and summarizes their potential clinical significance in gliomas.

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Implication of lncRNA ZBED3-AS1 downregulation in acquired resistance to Temozolomide and glycolysis in glioblastoma

Cited by 10 publications

References 38 publications

The prognostic relevance of a gene expression signature in MRI-defined highly vascularized glioblastoma

The prognostic relevance of a gene expression signature in MRI-defined highly vascularized glioblastoma

lncRNAs: New players of cancer drug resistance via targeting ABC transporters

The pathogenesis mechanism and potential clinical value of lncRNA in gliomas

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