Implication of dietary phenolic acids on inflammation in cardiovascular disease

Ali, Shafreena Shaukat; Ahmad, Wan Amir Nizam Wan; Budin, Siti Balkis; Zainalabidin, Satirah

doi:10.31083/j.rcm.2020.02.49

Cited by 38 publications

(12 citation statements)

References 125 publications

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“…The protective roles of dietary phenolics in the prevention of chronic diseases such as CVD and certain cancers have been extensively studied. The findings support the beneficial health effects of dietary phenolics including antiplatelet activity [51], antioxidative properties [52] and anti-inflammatory activity [53][54][55]. Furthermore, plant-based diets which provide a reliable source of phenolic compounds are reported to have a potential role in lowering the risk of cognitive disorders [56][57][58].…”

Section: Food and Health Among The Elderlysupporting

confidence: 62%

A Review Study of a Green Diet and Healthy Ageing

Fong

Chiu

Chan

et al. 2021

IJERPH

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Nowadays people are living longer, and there has been a substantial growth in the global elderly population in the past decades. While life expectancy is increasing, there are growing concerns towards the heavy financial and social burdens related to chronic diseases among the elderly. These have been critical health care issues, and healthy ageing is considered a top priority in public health. Diet and eating habits are crucial factors contributing to healthy ageing. These important aspects have attracted much attention in health research, particularly in consideration of the causes and management of chronic conditions which affect most elder adults in the world. Recently, a growing number of investigations have reported significant findings on the association of reduction in the risks of chronic non-communicable diseases with plant-based diets. Meanwhile, there have been worldwide initiatives and programmes implemented for reduction of salt intake. A green diet, which emphasises the consumption of a diet rich in plant foods with minimal portions of red or processed meat and reduced salt intake, is advocated with due consideration to the importance of sustainable environment and healthy ageing. This paper highlights a brief review of the recent advance of knowledge in diet and health, its effects on the elderly and the significance of a green diet on healthy ageing. Implications for a green diet and recommendations for future research are also discussed.

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Section: Food and Health Among The Elderlysupporting

confidence: 62%

A Review Study of a Green Diet and Healthy Ageing

Fong

Chiu

Chan

et al. 2021

IJERPH

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“…In this context, plant phenolic compounds (e.g., flavonoids, phenolic acids, lignins) have been described regarding their several pharmacological activities, including antioxidant, anti-inflammatory, hepatoprotective, and antimicrobial effects [ 12 ]. Polyphenols are the object of studies to develop new drugs due to their direct or indirect inhibition or activation of important cellular and molecular targets, by modulating the expression of inflammatory mediators [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Characterization of Flowers and Leaf Extracts Obtained from Turnera subulata and Their Immunomodulatory Effect on LPS-Activated RAW 264.7 Macrophages

et al. 2022

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The anti-inflammatory properties of Turnera subulata have been evaluated as an alternative drug approach to treating several inflammatory processes. Accordingly, in this study, aqueous and hydroalcoholic extracts of T. subulata flowers and leaves were analyzed regarding their phytocomposition by ultrafast liquid chromatography coupled to mass spectrometry, and their anti-inflammatory properties were assessed by an in vitro inflammation model, using LPS-stimulated RAW-264.7 macrophages. The phytochemical profile indicated vitexin-2-O-rhamnoside as an important constituent in both extracts, while methoxyisoflavones, some bulky amino acids (e.g., tryptophan, tyrosine, phenylalanine), pheophorbides, and octadecatrienoic, stearidonic, and ferulic acids were detected in hydroalcoholic extracts. The extracts displayed the ability to modulate the in vitro inflammatory response by altering the secretion of proinflammatory (TNF-α, IL-1β, and IL-6) and anti-inflammatory (IL-10) cytokines and inhibiting the PGE-2 and NO production. Overall, for the first time, putative compounds from T. subulata flowers and leaves were characterized, which can modulate the inflammatory process. Therefore, the data highlight this plant as an option to obtain extracts for phytotherapic formulations to treat and/or prevent chronic diseases.

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“…As a result of endothelial and intimal damage, cytosolic enzymes such as ALT and AST are released into the bloodstream with an increase in LDH activity and assist as the diagnostic indicators of myocardial tissue mutilation [ 39 ]. Ath is a well-known causative factor in myocardial tissue necrosis and heart dysfunctions marked by amplified end-diastolic volume, end-diastolic pressure, and left ventricular wall thickness.…”

Section: Discussionmentioning

confidence: 99%

Caffeic Acid Prevents Vascular Oxidative Stress and Atherosclerosis against Atherosclerogenic Diet in Rats

Wang

Kaur²,

Kumar

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Diet and lifestyle play a crucial role in the progress of some cardiovascular disorders (CVDs). Rising interest in natural products and their pharmacological investigations witnessed therapeutic potential against CVDs. Caffeic acid (CA) is an organic composite hydroxycinnamic acid derivative classified among phenolics. It is a secondary metabolite biosynthesized in all plant species in the form of ester conjugates. The reported pharmacological activities of CA are neuroprotective, cardioprotective, hypoglycemic, antioxidant, and immunomodulatory properties. This work is aimed to examine the outcome of CA in atherogenic diet- (Ath-) induced rat model on lipid profile changes and endothelium function. The method involves a study duration of 35 days utilizing (n = 6) male Wistar rats (180–200 g) that were fed either normal chow or Ath. Study groups are given (i) normal chow diet, (ii) Ath, (iii) Ath + CA (25 or 50 mg/kg, p.o.), (iv) normal chow diet + CA (50 mg/kg, p.o.), and (v) Ath + Atorvastatin (ATORVA) (5 mg/kg, p.o.). Blood samples were collected at the end of the study to measure serum lipid profile, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and tissue oxidative stress level. Hemodynamic parameters and aorta staining were performed. CA treatment ameliorated lipid profile and significantly reduced the oxidative stress level. Aorta staining examination revealed a marked reduction of the atherosclerotic lesions. These findings suggested that CA is an effective treatment approach for preventing atherosclerotic lesion progression attributed to protection against oxidative stress and various enzymatic activities in the Ath model.

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Implication of dietary phenolic acids on inflammation in cardiovascular disease

Cited by 38 publications

References 125 publications

A Review Study of a Green Diet and Healthy Ageing

A Review Study of a Green Diet and Healthy Ageing

Chemical Characterization of Flowers and Leaf Extracts Obtained from Turnera subulata and Their Immunomodulatory Effect on LPS-Activated RAW 264.7 Macrophages

Caffeic Acid Prevents Vascular Oxidative Stress and Atherosclerosis against Atherosclerogenic Diet in Rats

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