Health information technology (IT) has great potential to transform health care and inform population health goals in clinical research, quality measurement, and public safety. To fully realize the benefits of health IT for population health, we must focus on new models that maximize efficiency, encourage rapid learning, and protect patients' privacy. In this paper we explore the advantages of a networked model for analyzing population health information, providing several examples. Although broadening the use of networked models is challenging, the societal benefits of a networked model merit continued exploration and the development of workable solutions. [Health Affairs 28, no. 2 (2009) T h e r e i s g r e at p o t e n t i a l f o r health information technology (IT) to aid in achieving population health goals in the areas of clinical research, quality measurement, and public safety. 1 The need to improve health IT is driven by several factors: rising health care costs; well-documented gaps in quality; concern about safety and efficiency; a need for improved accountability; an increased awareness of bioterrorism as a possible threat; a need to monitor the safety and outcomes of drugs and treatments; and a call for studies of the comparative effectiveness of procedures for diagnosis and treatment. 2 IT can facilitate data collection and analysis across data sources and support the sharing of information in near real time across institutions, scientific disciplines, and geographic boundaries.