Implementing pre-exposure prophylaxis could prevent most new HIV infections in transsexual women and men who have sex with men

Ayerdi, Oskar; García, Mónica; Núñez, Julián; Lopez, Travis; Garcia, C. Escalante; Utrilla, Montserrat Raposo; Pérez, Vicente Estrada; Guerrero, Jorge Del Romero; Martín, C. Rodríguez

doi:10.1016/j.rceng.2019.02.010

Cited by 6 publications

(5 citation statements)

References 11 publications

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“…However, the use of preventive strategies such as PEP (3.8%) or PrEP (1.1%) was very rare in our study. The comparatively late funding in the implementation of PrEP in Spain could be one of the factors that explains the slow decline in new cases compared with other European or North American countries [ 14 , 28 ]. Funding of PrEP, combined with the other measures used in our country, may represent an opportunity to achieve a more substantial reduction in the number of new cases.…”

Section: Discussionmentioning

confidence: 99%

Changes in the profile of newly HIV-diagnosed men who have sex with men, Madrid, 2014 to 2019

et al. 2021

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Introduction Knowing the factors associated with HIV transmission is necessary in order to design preventive programmes tailored to the epidemiological situation in each region and population. Aim Our objective was to study the sociodemographic, clinical and behavioural characteristics of men who have sex with men (MSM) who were newly diagnosed with HIV infection. Methods We carried out an observational, descriptive, study on all MSM newly diagnosed with HIV infection in one clinic for sexually transmitted infections (STI) and HIV clinic in Madrid between 2014 and 2019. Information on sociodemographic, clinical, and behavioural characteristics of participants per year of diagnosis was collected. Results We detected a total of 1,398 people with HIV infection, 253 of whom were recent seroconverters (rSCV) with a median duration of documented seroconversion of 6 months. From the total, 97.9% infections were sexually transmitted and 2.1% involved injected drugs, i.e. slam practices. The average age was 32.9 years (range: 15.6–74.9), 51.8% were Spanish and 40% Latin American. These diagnoses decreased in Spanish people and increased in Latin Americans during the study period. Of the rSCV, 73.9% had condomless sex under the influence of drugs and 28.9% participated in chemsex sessions. Apps were used by 92.6% rSCV for sexual encounters and 70.4% of them attributed HIV transmission to their use. Conclusions Combination of HIV prevention strategies, as pre-exposure prophylaxis, should be reinforced among young MSM, especially those born in Latin America, those who use drugs for sex, and those who use apps in search of sexual contacts.

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Section: Discussionmentioning

confidence: 99%

Changes in the profile of newly HIV-diagnosed men who have sex with men, Madrid, 2014 to 2019

et al. 2021

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“…Finally, 44 original studies represented in 45 peer‐reviewed articles were included. See Figure 1 [10–42] [43–53].…”

Section: Resultsmentioning

confidence: 99%

PrEP for women in Europe: a systematic literature review

et al. 2023

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Background: Prevention of HIV transmission is fundamental to ending the HIV epidemic. Pre-exposure prophylaxis (PrEP) with oral tenofoviremtricitabine (TDF-FTC) is an established HIV-prevention method; however, most PrEP services in Europe have been targeted at men who have sex with men (MSM). A survey in 2021 by Women Against Viruses in Europe (WAVE) showed considerable variation in PrEP access and guidance for women throughout Europe. WAVE therefore commissioned this systematic review to provide insight into PrEP provision and barriers to uptake for women in Europe.Methods: PubMed, Embase, and Scopus were searched for studies (January 2013-May 2021) that reported on actual (e.g., efficacy and safety) or hypothetical (e.g., awareness, barriers, PrEP impact models) use of oral PrEP involving women (including cis, transgender, pregnant, migrant, and breastfeeding women). Search terms included HIV, pre-exposure prophylaxis (specifically TDF-FTC), and women. Studies performed outside of the World Health Organization European region were excluded. Results:The search identified 4716 unique citations, and 45 peer-reviewed articles (44 studies) were included. The majority of these studies (34/44 [77%])

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“…These data support the study by Shamu et al (2021), which, although multiple sexual partners are a risk factor for HIV infection, individuals in a stable relationship can also be exposed to the virus. This underscores the need to disseminate combined prevention strategies in combating HIV and other STIs (Ayerdi et al, 2019). Since 2012, the World Health Organization (WHO) has recommended the implementation of projects to demonstrate the safety, effectiveness, applicability, and sustainability of PrEP in serodiscordant couples (Hallal et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Access and use of pre-exposure prophylaxis for HIV in the city of Santa Maria, RS

Galvão,

Ziani,

Nogara

et al. 2024

DS-CS

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Pre-Exposure Prophylaxis (PrEP) for Human Immunodeficiency Virus (HIV) began to be offered in the city of Santa Maria, in the central region of Rio Grande do Sul (Brazil), in November 2020, and until August 2022 it was intended for key populations considered more exposed to HIV infection. Due to the short time of PrEP use in the city, limited information on access and utilization of prophylaxis is available. Thus, this study aimed to identify the sociodemographic profile and PrEP use in the city of Santa Maria. Data from 180 users who initiated prophylaxis between November 2020 and August 2022 were analyzed. Of these, 103 (57.3%) were correctly adhering to prophylaxis, while 77 (42.7%) discontinued its use. The sociodemographic profile of users consisted of cisgender men, homosexuals, white, aged between 18 and 24 years old, with ≥12 years of education, without a stable relationship, and residing in the central region. Regarding PrEP use, 78.8% (n=142/180) belonged to the population of gays and other men who have sex with men, 62.8% (n=113/180) were regularly using the medication, and 75% (n=135/180) reported no adverse events related to PrEP. A low incidence of sexually transmitted infections was observed. The results underscore the need for strategies aimed at reaching the population most vulnerable to HIV infection in the city and understanding the factors leading to its discontinuation.

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Implementing pre-exposure prophylaxis could prevent most new HIV infections in transsexual women and men who have sex with men

Cited by 6 publications

References 11 publications

Changes in the profile of newly HIV-diagnosed men who have sex with men, Madrid, 2014 to 2019

Changes in the profile of newly HIV-diagnosed men who have sex with men, Madrid, 2014 to 2019

PrEP for women in Europe: a systematic literature review

Access and use of pre-exposure prophylaxis for HIV in the city of Santa Maria, RS

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