This paper proposes the revamp of architecture of an eNodeB (eNB) for 5G cellular communication networks capable of opening up the crunched spectrum resources. We have developed a novel priority driven Resource Block (RB) handoff algorithm for Full-Duplex Multi-User MIMO communication, where the eNB creates beams for establishing communication links. The use of Full-Duplex operation enables simultaneous in-band uplink and downlink operation without sacrificing temporal resource in each link. Space-division multiple access (SDMA) technique has been used to dynamically create a beam towards the intended mobile users as well as track them through beam steering. The possibility of co-channel interference (CCI) due to mobility of users is eliminated by the introduction of RB handoff mechanism. This allows sharing of a RB or RBs by multiple users. In the proposed architecture, along with coexistence of multiple mobile UEs in same RBs diversity gain is introduced both in uplink and downlink. The work includes related simulations showing the conceptual validity of the proposed architecture to revamp. The proposed eNB model leads to improved QoS and a significant decrease in cellular spectrum requirement worth millions of dollars.