“…The proposal presented here is based on the general assumption that the environment on which it is developed has the characteristics of an SC4.0, i.e., an SC whose digital transformation is aligned with the design principles governing I4.0 and is carried out by using its enabling technologies. In this particular case, specifically some design principles of I4.0, such as flexibility, intelligence, integration, virtualization, interconnectedness, interoperability, visibility, real-time action ability, energy efficiency and sustainability [79][80][81][82] play a relevant role directly or indirectly in the endeavor to confront SC complexity and heterogeneity toward more resilience and sustainability on the way toward SC4.0. The same applies for some of its enabling technologies, such as information and communication technologies (ICT), cyber-physical systems (CPS) or cyber-physical production systems (CPPS), the Internet of things (IoT) or the industrial IoT (IIoT), smart enterprise resource planning (ERP), manufacturing execution system (MES), virtual reality, DT, ML algorithms, big data, cloud services or cloud manufacturing, semantic technologies and cybersecurity [79,81,[83][84][85], which are involved in the design of the proposal, along with techniques such as modeling, simulation and optimization.…”