Implementation of mDoE‐methods to a microcarrier‐based expansion processes for mesenchymal stem cells
Kim B. Kuchemüller,
Ralf Pörtner,
Johannes Möller
Abstract:The need for advanced therapy medicinal products (ATMPs) has gained increased attention in recent years. In this respect, a well‐designed cell expansion process is needed to efficiently manufacture the required number of cells with the desired product quality. This step is challenging due to the biological complexity of the respective primary cell (e.g., mesenchymal stem cells (MSC)) and the usage of microcarrier‐based expansion systems. One accelerating approach for process design is model‐assisted Design of … Show more
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