Implementation of RF-KO Extraction at CNAO

Savazzi, Simone; Bressi, Erminia; Debernardi, Giovanni; Falbo, Luciano; Lante, Valeria; Meliga, Paolo; Priano, C.; Pullia, M.; Russo, G.

doi:10.18429/jacow-ipac2019-thpmp010

Cited by 3 publications

(1 citation statement)

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“…The second technique requires the de-bunching of the beam, which makes further re-acceleration (or deceleration) theoretically possible (RF front acceleration), but extremely challenging, loss prone and potentially time consuming. Facilities not originally designed for MEE operation exhibit the trend to implement RF-KO first rather than attempting other retro-fitted techniques ( 56 – 58 ). The direction of energy change is typically fixed (e.g.…”

Section: Limitations and Avenues For Improvementsmentioning

confidence: 99%

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

2021

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The physical and clinical benefits of charged particle therapy (CPT) are well recognized. However, the availability of CPT and complete exploitation of dosimetric advantages are still limited by high facility costs and technological challenges. There are extensive ongoing efforts to improve upon these, which will lead to greater accessibility, superior delivery, and therefore better treatment outcomes. Yet, the issue of cost remains a primary hurdle as utility of CPT is largely driven by the affordability, complexity and performance of current technology. Modern delivery techniques are necessary but limited by extended treatment times. Several of these aspects can be addressed by developments in the beam delivery system (BDS) which determines the overall shaping and timing capabilities enabling high quality treatments. The energy layer switching time (ELST) is a limiting constraint of the BDS and a determinant of the beam delivery time (BDT), along with the accelerator and other factors. This review evaluates the delivery process in detail, presenting the limitations and developments for the BDS and related accelerator technology, toward decreasing the BDT. As extended BDT impacts motion and has dosimetric implications for treatment, we discuss avenues to minimize the ELST and overview the clinical benefits and feasibility of a large energy acceptance BDS. These developments support the possibility of advanced modalities and faster delivery for a greater range of treatment indications which could also further reduce costs. Further work to realize methodologies such as volumetric rescanning, FLASH, arc, multi-ion and online image guided therapies are discussed. In this review we examine how increased treatment efficiency and efficacy could be achieved with improvements in beam delivery and how this could lead to faster and higher quality treatments for the future of CPT.

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Section: Limitations and Avenues For Improvementsmentioning

confidence: 99%

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

2021

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Pulsed RF knock-out extraction: a potential enabler for FLASH hadrontherapy in the Bragg peak

Waid,

Gsponer,

Renner

et al. 2024

Phys. Med. Biol.

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One challenge on the path to delivering FLASH-compatible beams with a synchrotron is facilitating an accurate dose control for the required ultra-high dose rates. We propose the use of pulsed RFKO extraction instead of continuous beam delivery as a way to control the dose delivered per Voxel. In a first feasibility test, dose rates in pulses of up to 600 Gy/s were observed, while the granularity at which the dose was delivered is expected to be well below 0.5 Gy.

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A Novel Facility for Cancer Therapy and Biomedical Research with Heavy Ions for the South East European International Institute for Sustainable Technologies

Damjanovic¹,

Amaldi²,

Benedetto³

et al. 2021

Proceedings of the 12th International Particle Accelerator Conference

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Implementation of RF-KO Extraction at CNAO

Cited by 3 publications

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Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

Future Developments in Charged Particle Therapy: Improving Beam Delivery for Efficiency and Efficacy

Pulsed RF knock-out extraction: a potential enabler for FLASH hadrontherapy in the Bragg peak

A Novel Facility for Cancer Therapy and Biomedical Research with Heavy Ions for the South East European International Institute for Sustainable Technologies

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