Implementation of response surface methodology to assess the antiradical behaviour in mixtures of ascorbic acid and α-tocopherol with grape (Vitis vinifera) stem extracts

Karvela, Evangelia; Makris, Dimitris P.; Karathanos, Vaios Τ.

doi:10.1016/j.foodchem.2011.10.091

Cited by 22 publications

(16 citation statements)

References 21 publications

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“…Similar findings have been previously reported [29]. In any case, it could be speculated that the differences in the antioxidant potency seen between the LTTM and the aqueous methanolic extract, might reflect differences in the relative amounts of the polyphenolic antioxidants, as well as phenomena of synergism and antagonism [27]. The latter aspect is strongly supported by the fact that OLL may behave as a more powerful antioxidant than its individual polyphenols [30].…”

Section: Assessment Of Model Validity and Extraction Efficiencysupporting

confidence: 84%

“…The antioxidant activity measured in OLL extracts has been suggested to be the outcome of interactions amongst the various polyphenolic substances [26], a claim further supported by studies that assessed the antiradical behaviour of mixtures of pure antioxidants and extracts [27]. The discrepancy observed regarding the weak antioxidant effects of the LTTM extract, in spite its high polyphenol concentration, may be attributed to differences in the amount of flavonoids and other phenolics, major representative of which is oleuropein.…”

Section: Assessment Of Model Validity and Extraction Efficiencymentioning

confidence: 94%

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Ultrasound-Assisted Extraction of Polyphenolic Antioxidants from Olive (Olea europaea) Leaves Using a Novel Glycerol/Sodium-Potassium Tartrate Low-Transition Temperature Mixture (LTTM)

et al. 2017

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Abstract:Olive leaves (OLL) represent a major waste generated during the production of olive oil, but there is a great potential for their valorization, because they provide important content in polyphenolic phytochemicals, which possess several bioactivities. In spite of the high number of studies dealing with polyphenol recovery from olive leaves, green processes involving environmentally benign solvents are scarce. In this study, a novel renewable natural low-transition temperature mixture (LTTM), composed of glycerol and sodium-potassium tartrate, was tested for its efficient ability to extract polyphenolic substances from OLL. The extraction process was optimised by using response surface methodology and the maximum yield in total polyphenols was 26.75 ± 3.22 mg caffeic acid equivalents per g dry weight, achieved with 50% (v/v) aqueous LTTM, liquid-to-solid ratio of 45 mL g −1 and at 73 • C. The LTTM was proven to be equally effective with 60% aqueous methanol, but it displayed inferior antioxidant properties. Liquid chromatography-diode array-mass spectrometry analyses revealed no significant qualitative differences between the LTTM and the aqueous methanolic extract.

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Section: Assessment Of Model Validity and Extraction Efficiencysupporting

confidence: 84%

Section: Assessment Of Model Validity and Extraction Efficiencymentioning

confidence: 94%

Ultrasound-Assisted Extraction of Polyphenolic Antioxidants from Olive (Olea europaea) Leaves Using a Novel Glycerol/Sodium-Potassium Tartrate Low-Transition Temperature Mixture (LTTM)

et al. 2017

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“…Nevertheless, mixture effects that can be manifested either as synergism or antagonism among the various polyphenols occurring in the extracts should also be considered. Such phenomena were demonstrated for A AR in mixtures of antioxidants [42] and mixtures of antioxidants with plant extracts [43]. Similar mixture effects for P R have also been found [44].…”

Section: Antioxidant Activitysupporting

confidence: 69%

Combination of Lactic Acid-Based Deep Eutectic Solvents (DES) with β-Cyclodextrin: Performance Screening Using Ultrasound-Assisted Extraction of Polyphenols from Selected Native Greek Medicinal Plants

et al. 2017

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Abstract:A series of novel L-lactic acid-based deep eutectic solvents (DES) were tested for polyphenol extraction performance, using organically grown, native Greek medicinal plants. The extractions were ultrasonically-assisted and the effect of the addition of β-cyclodextrin (β-CD) as extraction booster was also tested, at a concentration of 1.5% (w/v). The estimation of total polyphenol yield (Y TP ) suggested that DES composed of L-lactic acid and nicotinamide and L-lactic acid and L-alanine, both at a molar ratio of 7:1, are promising solvents giving significantly higher yields compared with 60% (v/v) aqueous ethanol and water. However, when β-CD was combined with DES comprised of L-lactic acid and ammonium acetate (molar ratio 7:1), the extraction yields obtained in some instances were equal of even higher. The pattern was not consistent when the yield in total flavonoids (Y TFn ) was considered, indicating water, 60% (v/v) aqueous ethanol and L-lactic acid:sodium acetate (molar ratio 7:1) to be the most efficient solvents. In this case, the effect of β-CD was of rather lower magnitude. The examination of the antioxidant activity of the extracts generated showed that there is a close correlation mainly with their concentration in total polyphenols.

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“…The positive effect exerted by C gl on both A AR and P R could be ascribed to the fact that the higher C gl promoted higher Y TP . In several instances, the antioxidant effects manifested by polyphenol-containing extracts are directly proportional to polyphenol concentration [33], although this is not a universal principle because of phenomena of synergism and/or antagonism amongst different polyphenols [34]. However, it is likely that similar phenomena amongst the entrapped polyphenols could be hindered owed to steric effects; their impact would therefore be quite minimal, if not null.…”

Section: Resultsmentioning

confidence: 99%

Optimization of a Green Extraction/Inclusion Complex Formation Process to Recover Antioxidant Polyphenols from Oak Acorn Husks (Quercus Robur) Using Aqueous 2-Hydroxypropyl-β-Cyclodextrin/Glycerol Mixtures

et al. 2016

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Aqueous mixtures of glycerol and 2-hydroxypropyl-β-cyclodextrin (CD), two non-toxic eco-friendly substances, were used as a means of extracting antioxidant polyphenols from oak acorn (Quercur robur) husks. The process was optimized by implementing a central composite (Box-Behnken) experimental design and response surface methodology, taking into consideration the critical parameters (independent variables) of glycerol concentration (C gl ), CD concentration (C CD ) and temperature (T). The assessment of the extraction model was based on three responses: the total polyphenol yield (Y TP ), the antiradical activity (A AR ) and the reducing power (P R ). The model illustrated that Y TP depended significantly on C gl and C CD , but not on T, whereas both antioxidant properties considered (A AR and P R ) were temperature-dependent. The maximum predicted Y TP was 122.19 mg GAE per g dry husk weight, while the extract obtained under optimized conditions displayed strong antioxidant activity.

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Implementation of response surface methodology to assess the antiradical behaviour in mixtures of ascorbic acid and α-tocopherol with grape (Vitis vinifera) stem extracts

Cited by 22 publications

References 21 publications

Ultrasound-Assisted Extraction of Polyphenolic Antioxidants from Olive (Olea europaea) Leaves Using a Novel Glycerol/Sodium-Potassium Tartrate Low-Transition Temperature Mixture (LTTM)

Ultrasound-Assisted Extraction of Polyphenolic Antioxidants from Olive (Olea europaea) Leaves Using a Novel Glycerol/Sodium-Potassium Tartrate Low-Transition Temperature Mixture (LTTM)

Combination of Lactic Acid-Based Deep Eutectic Solvents (DES) with β-Cyclodextrin: Performance Screening Using Ultrasound-Assisted Extraction of Polyphenols from Selected Native Greek Medicinal Plants

Optimization of a Green Extraction/Inclusion Complex Formation Process to Recover Antioxidant Polyphenols from Oak Acorn Husks (Quercus Robur) Using Aqueous 2-Hydroxypropyl-β-Cyclodextrin/Glycerol Mixtures

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