Implementation of Quality by Design (QbD) for development of bilayer tablets

Enhancing Nose- To- Brain Delivery of Piribedil: Development of a Nanosuspension Dispersed in Nasal in-Situ Gelling System

“…The evaluation of diffusion serves as a critical indicator of permeation properties, elucidating the substance's ability to pass through barriers [35]. In the context of this study, the utilized membrane possessed a pore size of 100 nm, rendering the direct passage of Piribedil particles unfeasible.…”

“…Particularly noteworthy is the fact that within the initial 15 min, F2 saw the diffusion of 13.14 µg cm −2 of the drug, compared to a mere 0.48 µg cm −2 from R2. This elevated diffusion can be attributed to the amplified surface area achieved through nanoparticle formation, underscoring the advantageous impact of nanosizing on drug permeation [35]. As we delve deeper into the cutting-edge issue of nanotechnology, it becomes clear that it is an important component of their use in a range of compositions to maximize the permeability of various medicinal substances.…”

“…QbD approaches involve predicting and achieving formulation quality by controlling relevant parameters and reducing the wastage of excipients inherent in trial-and-error approaches. Successful QbD application necessitates the comprehensive study of formulation variables and their interactions [34,35].…”

Bilayer tablet overview: A revolutionary approach in sustained drug release & combination drug therapy

“…Plastic materials compress because of plastic flow, whereas brittle materials break and fill up spaces when compression force is applied. 4. Take into account the variations in the elastic Young's modulus.…”

“…17. For adequate interfacial strength to endure mechanical shock during manufacture, packaging, and transportation, bristle excipients are preferred [4].…”