Implementation of quality by design approach for optimization of the green voltammetric analysis of a brain doping agent (Piracetam) using a novel molecular imprinted polymeric sensor

Medhat, Passant M.; Mohamed Fouad, Manal; Mahmoud, Amr M.; Ghoniem, Nermine S.; Monir, Hany H.

doi:10.1016/j.microc.2024.111347

Microchemical Journal

2024

DOI: 10.1016/j.microc.2024.111347

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Implementation of quality by design approach for optimization of the green voltammetric analysis of a brain doping agent (Piracetam) using a novel molecular imprinted polymeric sensor

Passant M. Medhat,

Manal Mohamed Fouad,

Amr M. Mahmoud

et al.

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2024

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Cited by 2 publications

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Electrochemical Sensor based on N-Doped Graphite/Aluminum Silicate Nanocomposite Modified Carbon Paste for Simultaneous Detection of Paracetamol and Pamabrom

Sawan,

Merey,

Mahmoud

et al. 2024

J. Electrochem. Soc.

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We have developed an eco-friendly sensor through innovative modification of a carbon paste electrode with nanomaterials. This modification is based on employing a mixture of aluminum silicate and nitrogen-doped graphite nanocomposite (Al2SiO5/NG/CPE), introducing the first electrochemical approach for the voltammetric determination of a combination of paracetamol (PCM) and pamabrom (PAM), which is recognized as an over-the-counter remedy for menstrual cramp relief. N-doped graphite was prepared from graphite and urea using a metal-free soft nitriding method. The morphological characterization of the Al2SiO5/NG nanocomposite was investigated using transmission electron microscopy, energy dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. The experimental conditions were optimized using square wave voltammetry and cyclic voltammetry techniques to explore the impact of scan rate, pH, and concentration. The results exhibited good linearity across a wide concentration range of 0.2 nM–100.0 μM for both drugs. The limits of detection for PCM and PAM were 25 and 24 pM, respectively, while the limits of quantification were 88.3 and 80.0 pM, showing the proposed sensor’s exceptional sensitivity. Furthermore, the proposed sensor was employed to determine the PCM/PAM mixture in bulk powder, pharmaceutical dosage forms, biological fluids, and in the presence of toxic paracetamol metabolites.

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Electrochemical Sensor based on N-Doped Graphite/Aluminum Silicate Nanocomposite Modified Carbon Paste for Simultaneous Detection of Paracetamol and Pamabrom

Sawan,

Merey,

Mahmoud

et al. 2024

J. Electrochem. Soc.

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Curcumin-Based Molecularly Imprinted Polymer Electropolymerized on Single-Use Graphite Electrode for Dipyridamole Analysis

Preda,

Radu,

Iorgulescu

et al. 2024

Molecules

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A new molecularly imprinted polymer (MIP)-based disposable electrochemical sensor for dipyridamole (DIP) determination was obtained. The sensor was rapidly prepared by potentiodynamic electrochemical polymerization on a pencil graphite electrode (PGE) using curcumin (CUR) as a functional monomer and DIP as a template molecule. After the optimization of the conditions (pH, monomer–template ratio, scan rate, number of cyclic voltammetric cycles applied in the electro-polymerization process and extraction time of the template molecule) for MIP formation, DIP voltammetric behavior at the modified electrode (MIP_PGE) was investigated. DIP oxidation took place in a pH-dependent, irreversible mixed diffusion-adsorption controlled process. Differential pulse voltammetry (DPV) and adsorptive stripping differential pulse voltammetry (AdSDPV) were used to quantify DIP from pharmaceutical and tap water samples. Under optimized conditions (Britton–Robinson buffer at pH = 3.29), the obtained linear ranges were 5.00 × 10−8–1.00 × 10−5 mol/L and 5.00 × 10−9–1.00 × 10−7 mol/L DIP for DPV and AdSDPV, respectively. The limits of detection of the methods were 1.47 × 10−8 mol/L for DPV and 3.96 × 10−9 mol/L DIP for AdSDPV.

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Implementation of quality by design approach for optimization of the green voltammetric analysis of a brain doping agent (Piracetam) using a novel molecular imprinted polymeric sensor

Cited by 2 publications

References 52 publications

Electrochemical Sensor based on N-Doped Graphite/Aluminum Silicate Nanocomposite Modified Carbon Paste for Simultaneous Detection of Paracetamol and Pamabrom

Electrochemical Sensor based on N-Doped Graphite/Aluminum Silicate Nanocomposite Modified Carbon Paste for Simultaneous Detection of Paracetamol and Pamabrom

Curcumin-Based Molecularly Imprinted Polymer Electropolymerized on Single-Use Graphite Electrode for Dipyridamole Analysis

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