Implementation of point-of-care testing in a pediatric healthcare setting

Patel, Khushbu; Suh-Lailam, Brenda B.

doi:10.1080/10408363.2019.1590306

Cited by 24 publications

(28 citation statements)

References 44 publications

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“…23 One reason for this is that it is more efficient to maximize the use of an existing machine with a high fixed cost over POC testing where testing cartridges have a relatively higher variable cost that changes with utilization volume. 6 , 10 When there is the capacity to process blood gases rapidly within the existing diagnostic laboratory easily, the CL machine is used most efficiently. Additionally, time is also freed up for other staff to provide value-added work, and the use of the CL minimizes the chances of preanalytic errors by clinical staff that may occur with POC test samples.…”

Section: Discussionmentioning

confidence: 99%

“…Rapid point-of-care (POC) testing is an expanding area of diagnostic testing in pediatrics. 6 , 7 POC blood gas testing delivers rapid and accurate results, allowing assessment of metabolic and respiratory status in critical situations and prompt initiation of treatments. 8 , 9 This has led to POC blood gas tests becoming more frequent or even standard options in several care settings, including the pediatric intensive care unit (PICU) and the emergency department.…”

Section: Introductionmentioning

confidence: 99%

“… 8 , 9 This has led to POC blood gas tests becoming more frequent or even standard options in several care settings, including the pediatric intensive care unit (PICU) and the emergency department. 6 However, over-reliance on POC testing may both reduce value and increase the waste of hospital resources. First, POC testing may be more expensive than the main or central laboratory (CL) testing.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Reducing Point-of-care Blood Gas Testing in the Intensive Care Unit through Diagnostic Stewardship: A Value Improvement Project

Tchou

May

Holcomb

et al. 2020

Pediatric Quality &Amp; Safety

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show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Reducing Point-of-care Blood Gas Testing in the Intensive Care Unit through Diagnostic Stewardship: A Value Improvement Project

Tchou

May

Holcomb

et al. 2020

Pediatric Quality &Amp; Safety

View full text Add to dashboard Cite

show abstract

“…It is also essential for reducing drug-related adverse effects and reducing unnecessary medical costs 23,30 . In the case of antibiotics, an accurate diagnosis also leads to a reduction of the over-prescription of antibiotics as well as inappropriate prescription of antibiotics in viral infections both of which are contributing to the accelerated development of antibiotic resistance 16,[31][32][33] .…”

Section: Bacillus Anthracismentioning

confidence: 99%

Challenge of diagnosing acute infections in poor resource settings in Africa

Chidzwondo

Mutapi

2021

Open Res Africa

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Frequent disease outbreaks and acute infections occur in rural and low-income urban areas of Africa, with many health systems unprepared to diagnose and control diseases that are recurrent, endemic or have extended their geographic zone. In this review, we focus on acute infections that can be characterized by sudden onset, rapid progression, severe symptoms and poor prognosis. Consequently, these infections require early diagnosis and intervention. While effective vaccines have been developed against some of these diseases, lack of compliance and accessibility, and the need for repeated or multiple vaccinations mean large populations can remain vulnerable to infection. It follows that there is a need for enhancement of national surveillance and diagnostic capacity to avert morbidity and mortality from acute infections. We discuss the limitations of traditional diagnostic methods and explore the relative merits and applicability of protein-, carbohydrate- and nucleic acid-based rapid diagnostic tests that have been trialled for some infectious diseases. We also discuss the utility and limitations of antibody-based serological diagnostics and explore how systems biology approaches can better inform diagnosis. Lastly, given the complexity and high cost associated with after-service support of emerging technologies, we propose that, for resource-limited settings in Africa, multiplex point-of-care diagnostic tools be tailor-made to detect both recurrent acute infections and endemic infections.

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“…Point-of-care diagnostics (POCD) for health monitoring involves the evaluation of indices from human health through tests performed outside of the clinical laboratory, typically right at the site of patient care [1,2,3,4]. While the advantages of POCD such as rapid diagnosis, operational efficiency, and costs have been well established [2], widespread implementation of this technology has not yet been achieved [5]. One of the main limitations of POCD is the requirement of unprocessed test samples drawn from patients to provide the desired sensitivity and specificity for conducting reliable assays in situ.…”

Section: Introductionmentioning

confidence: 99%

Acoustofluidic Micromixing Enabled Hybrid Integrated Colorimetric Sensing, for Rapid Point-of-Care Measurement of Salivary Potassium

et al. 2019

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The integration of microfluidics with advanced biosensor technologies offers tremendous advantages such as smaller sample volume requirement and precise handling of samples and reagents, for developing affordable point-of-care testing methodologies that could be used in hospitals for monitoring patients. However, the success and popularity of point-of-care diagnosis lies with the generation of instantaneous and reliable results through in situ tests conducted in a painless, non-invasive manner. This work presents the development of a simple, hybrid integrated optical microfluidic biosensor for rapid detection of analytes in test samples. The proposed biosensor works on the principle of colorimetric optical absorption, wherein samples mixed with suitable chromogenic substrates induce a color change dependent upon the analyte concentration that could then be detected by the absorbance of light in its path length. This optical detection scheme has been hybrid integrated with an acoustofluidic micromixing unit to enable uniform mixing of fluids within the device. As a proof-of-concept, we have demonstrated the real-time application of our biosensor format for the detection of potassium in whole saliva samples. The results show that our lab-on-a-chip technology could provide a useful strategy in biomedical diagnoses for rapid analyte detection towards clinical point-of-care testing applications.

show abstract

Implementation of point-of-care testing in a pediatric healthcare setting

Cited by 24 publications

References 44 publications

Reducing Point-of-care Blood Gas Testing in the Intensive Care Unit through Diagnostic Stewardship: A Value Improvement Project

Reducing Point-of-care Blood Gas Testing in the Intensive Care Unit through Diagnostic Stewardship: A Value Improvement Project

Challenge of diagnosing acute infections in poor resource settings in Africa

Acoustofluidic Micromixing Enabled Hybrid Integrated Colorimetric Sensing, for Rapid Point-of-Care Measurement of Salivary Potassium

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