Implementation of metal-free ring-opening polymerization in the preparation of aliphatic polycarbonate materials

PEGylated and Functionalized Aliphatic Polycarbonate Polyplex Nanoparticles for Intravenous Administration of HDAC5 siRNA in Cancer Therapy

“…Such fine-tuned synthetic polymer vector can be produced through a metal-free polymerization process involving nontoxic catalysts in mild conditions and giving access to any kind of functional polymers and topologies. [33][34][35] The objective of the present work is to further modify these polymers to enable them to overcome the extracellular barriers and induce biological activity in vivo following intravenous injection. Once intravenously injected, polyplexes may interact with different components of the bloodstream.…”

Microwave energy assisted synthesis of poly lactic acid via continuous reactive extrusion: modelling of reaction kinetics

“…Several attempts were made to substitute tin-based catalysts by catalysts that exhibit less toxicity or eco-toxicity. [8][9][10][11][12][13][14][15][16] Typically, the alternative catalysts require a higher amount of energy of activation. 17 Initial experimental trials support the use of alternative energy sources (LASER, Ultrasounds, microwaves) to facilitate the ROP of lactide monomers.…”

Poly(trimethylene carbonate)/Poly(malic acid) Amphiphilic Diblock Copolymers as Biocompatible Nanoparticles

“…[3][4][5][6][7] In particular,p oly(1,3-trimethylene carbonate) (PTMC) is the most investigated PC regarding both its synthesisa nd applications. [8][9][10][11][12] Indeed, as aP Cd erived form ab iosourced monomer (TMC can indeed be produced from glycerol, ab yproduct of biodieselp roduction from vegetable and animal fat triglycerides), [13][14][15] PTMC is currently attracting increasinga ttention within current environmental considerations. [8][9][10][11][12] Additionally, PTMC featuresv aluable mechanical softness [16] that is favorably exploited, in particular,t owards the designo fc opolymers such as the thermoplasticP TMC-bpoly(l-lactide)e lastomers.…”

“…[8][9][10][11][12] Indeed, as aP Cd erived form ab iosourced monomer (TMC can indeed be produced from glycerol, ab yproduct of biodieselp roduction from vegetable and animal fat triglycerides), [13][14][15] PTMC is currently attracting increasinga ttention within current environmental considerations. [8][9][10][11][12] Additionally, PTMC featuresv aluable mechanical softness [16] that is favorably exploited, in particular,t owards the designo fc opolymers such as the thermoplasticP TMC-bpoly(l-lactide)e lastomers. [17][18][19][20][21][22][23] Other PTMC homopolymers [24][25][26][27] and copolymers associating, in particular,p oly(ethylene glycol) (PEG) [28][29][30][31][32][33][34][35][36][37][38] or poly(glutamic acid) (PGA) [39][40][41][42][43] segments [44][45][46][47] in spontaneously self-assemblingp olymeric structures, as well as otherP C-b...…”

“…PMLA(Be)-based copolymers have thus been investigated as amphiphilic self-assembled PHA copolymers for thed esign of drug nanocarriers. [68][69][70] PCs and PHAs can be synthesized through controlled ROP of cyclic carbonates [8][9][10][11][12] and b-lactones, [71][72][73][74][75] respectively. [76] The ROP process enables fine-tuning of macromolecular features, such as achieving ap redictable molar mass;l ow dispersity; limiting undesirable side reactions, such as transesterifications/ transcarbonations; end-group fidelity;a nd tailored microstructures (regio-/stereoregularity of the macromolecule).…”