Implementation of Mathematical Models to Predict New Cannabis Use by Urine Drug Testing: It Is Time to Move Forward

Breindahl, Torben; Kimergård, Andreas; Leutscher, Peter; Hindersson, Peter

doi:10.1093/jat/bkab037

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…Future studies should obtain twice weekly creatinine-corrected quantitative THC-COOH levels using chromatographic and mass spectrometric methods. Applying a mathematical model (e.g., Schwilke et al 66 ) to these THC-COOH levels can determine, with a high degree of certainty, if cannabis abstinence was indeed sustained 67 .…”

Section: Discussionmentioning

confidence: 99%

Investigating repetitive transcranial magnetic stimulation on cannabis use and cognition in people with schizophrenia

Bidzinski

Lowe

Sanches³

et al. 2022

Schizophr

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Cannabis use disorder (CUD) occurs at high rates in schizophrenia, which negatively impacts its clinical prognosis. These patients have greater difficulty quitting cannabis which may reflect putative deficits in the dorsolateral prefrontal cortex (DLPFC), a potential target for treatment development. We examined the effects of active versus sham high-frequency (20-Hz) repetitive transcranial magnetic stimulation (rTMS) on cannabis use in outpatients with schizophrenia and CUD. Secondary outcomes included cannabis craving/withdrawal, psychiatric symptoms, cognition and tobacco use. Twenty-four outpatients with schizophrenia and CUD were enrolled in a preliminary double-blind, sham-controlled randomized trial. Nineteen participants were randomized to receive active (n = 9) or sham (n = 10) rTMS (20-Hz) applied bilaterally to the DLPFC 5x/week for 4 weeks. Cannabis use was monitored twice weekly. A cognitive battery was administered pre- and post-treatment. rTMS was safe and well-tolerated with high treatment retention (~90%). Contrast estimates suggested greater reduction in self-reported cannabis use (measured in grams/day) in the active versus sham group (Estimate = 0.33, p = 0.21; Cohen’s d = 0.72), suggesting a clinically relevant effect of rTMS. A trend toward greater reduction in craving (Estimate = 3.92, p = 0.06), and significant reductions in PANSS positive (Estimate = 2.42, p = 0.02) and total (Estimate = 5.03, p = 0.02) symptom scores were found in the active versus sham group. Active rTMS also improved attention (Estimate = 6.58, p < 0.05), and suppressed increased tobacco use that was associated with cannabis reductions (Treatment x Time: p = 0.01). Our preliminary findings suggest that rTMS to the DLPFC is safe and potentially efficacious for treating CUD in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Investigating repetitive transcranial magnetic stimulation on cannabis use and cognition in people with schizophrenia

Bidzinski

Lowe

Sanches³

et al. 2022

Schizophr

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“…With the basic Reproduction Number ( 𝑅 0 ) of cannabis consumer at the SFC equilibrium state of this model, it is found that 𝐸 0 (𝑆 0 , 𝐸 0 , 𝐸 𝑁𝐵 0 , 𝐸 𝐵 0 , … … . ) = ( ˄ µ , 0,0,0,0,0,0,0,0,0,0)𝜖ℝ 11 .…”

Section: Basic Reproduction Number Of Cannabis Sativa Consumptionmentioning

confidence: 99%

“…Menetrey et al [9] developed a mathemathical model for the prediction of time of Cannabis exposure while Chapwanya et al [10] developed a model for Cannabis epidemic in a South African province with a non-linear incidence rate. Toben et al [11] looked at the implementation of mathematical models to predict new Cannabis use by urine drug testing: it is time to move forward, while Abramson et al [12] considered the importance of mathematical models to explore the effects of marijuana and other plant based products on learning and memory in their respective study. Saini et al [13] discussed a topic entitled 'Hempseed (Cannabis sativa L) bulk mass modelling based on engineering properties in their study'.…”

Section: Introductionmentioning

confidence: 99%

Mathematical Model on the Control/Eradication of the Consumption of Cannabis sativa in Afikpo North Local Government Area of Ebonyi State, Nigeria

Isienyi

Arihilam

Ujah

et al. 2023

CJAST

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The present work studied the dynamics of the interaction of the susceptible and victims of Cannabis sativa smoking/consumption using a mathematical model SEIR (Susceptible, Exposed, Infected, and Recovered/Removed) approach with sensitive control parameters introduced accordingly. We strive at developing a set of model equations from a schematic diagram designed as to enable us conduct some necessary analyses for the study. We derive a deterministic model on the control/eradication of Cannabis sativa smoking/consumption in Afikpo North Local Government Area of Ebonyi State via (a). Developing proper and all-encompassing schematic diagram from where the necessary differential equation will be generated for use for the research analyses, (b). Introducing/employing of ideal control parameters or measures at the right/vital compartments in the schematic diagram, (c). Conducting the three (3) relevant/basic analyses such as (i) Stability, (ii) Endemicity, (iii) Sensitivity analyses of the model equations, (d). Simulating the system using a derived sensitivity index table with the help of R0, and (e). Interpreting the resulting graphs that will provide the effective control measures on the use of Cannabis sativa. The results show that, of all the five (5) control parameters, τ (which is the enlightenment control on the dangers and health hazards associated with the use of Cannabis sativa) is the most effective. The Government is then advised to set up an agency to be saddled with the responsibility of conducting enough sensitization on the dangers as well as the health hazards associated with the use of Cannabis sativa.

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Implementation of Mathematical Models to Predict New Cannabis Use by Urine Drug Testing: It Is Time to Move Forward

Cited by 2 publications

References 21 publications

Investigating repetitive transcranial magnetic stimulation on cannabis use and cognition in people with schizophrenia

Investigating repetitive transcranial magnetic stimulation on cannabis use and cognition in people with schizophrenia

Mathematical Model on the Control/Eradication of the Consumption of Cannabis sativa in Afikpo North Local Government Area of Ebonyi State, Nigeria

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