The emergence of new piezoelectric materials makes it possible to offer high performances in terms of power densities and integration. These new materials can be used in DC-DC power converters as solution to replace the magnetic components and to meet the growth in demand of miniaturization, high power densities and high efficiency applications. This paper deals with a new topology of a DC-DC converter based on piezoelectric resonator. The conversion mechanism, based on energy and charge balance, is explained in details through an analytical model and validated by experimental results. A prototype has been designed for an input-output voltage up to 250-125 V and a power range of 100 W. It provides an efficiency higher than 93% for wide operating points in radial mode vibration. As an example, we obtain an efficiency 93.8 % of for 250 -117 V input-output voltage at 50 W output power. In addition, the thickness mode operation is experimentally validated at 1 MHz, and exhibited a peak output power of 175 W with an efficiency of 80 % for 200 -60 V inputoutput voltage. The experimental results show the promising performances of the proposed DC-DC power converter based on piezoelectric resonator for high-to-low voltage, high efficiency and low-to-medium power applications.