This paper designs a portable instrument for automobile wheel measurement, and details the measurement method and the hardware and software structures. Taking LPC2294 as its microcontroller, the instrument runs on the operating system uC/OS-II, adopts the graphical interface system MiniGUI, and uses multiple sensors. The main functions of the instrument include the measurement of the runout and press-fit depth and the harmonic analysis. The modular structure makes the instrument easy to move and carry. The instrument can be applied to measure various types of automobile wheels and enjoys a broad application potential.