Implementation of a solid target production facility

Tochon-Danguy, Henri; Poniger, Stan; Sachinidis, John; Panopoulos, H. P.; Scott, A. M.

doi:10.1063/1.4773962

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The metal impurities in the irradiated 64 Ni target were estimated using previously reported values [26,32,35,36]. The concentration of metal impurities can differ among laboratories because it depends on the cyclotron irradiation, mainly on the target and subsequent separation process.…”

Section: Discussionmentioning

confidence: 99%

Trace Metal Impurities Effects on the Formation of [64Cu]Cu-diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]Cu-ATSM)

Shinada,

Suzuki,

Hanyu

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

[64Cu]Cu-diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]Cu-ATSM) is a radioactive hypoxia-targeting therapeutic agent being investigated in clinical trials for malignant brain tumors. For the quality management of [64Cu]Cu-ATSM, understanding trace metal impurities’ effects on the chelate formation of 64Cu and ATSM is important. In this study, we conducted coordination chemistry studies on metal–ATSM complexes. First, the effects of nonradioactive metal ions (Cu2+, Ni2+, Zn2+, and Fe2+) on the formation of [64Cu]Cu-ATSM were evaluated. When the amount of Cu2+ or Ni2+ added was 1.2 mol or 288 mol, equivalent to ATSM, the labeling yield of [64Cu]Cu-ATSM fell below 90%. Little effect was observed even when excess amounts of Zn2+ or Fe2+ were added to the ATSM. Second, these metals were reacted with ATSM, and chelate formation was measured using ultraviolet–visible (UV-Vis) absorption spectra. UV-Vis spectra showed a rapid formation of Cu2+ and the ATSM complex upon mixing. The rate of chelate formation by Ni2+ and ATSM was lower than that by Cu-ATSM. Zn2+ and Fe2+ showed much slower reactions with the ATSM than Ni2+. Trace amounts of Ni2+, Zn2+, and Fe2+ showed little effect on [64Cu]Cu-ATSM’ quality, while the concentration of impurity Cu2+ must be controlled. These results can provide process management tools for radiopharmaceuticals.

show abstract

Section: Discussionmentioning

confidence: 99%

Trace Metal Impurities Effects on the Formation of [64Cu]Cu-diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]Cu-ATSM)

Shinada,

Suzuki,

Hanyu

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…Further on, the electrochemically plated deposits may have non-uniform thickness [31,46,74] and when the deposition is carried out from a solution with low metal content, the process can be time consuming (e.g. [2,8,10,13,17,19,45,48,[59][60][61][62][63][64][65][66]).…”

Section: Introductionmentioning

confidence: 99%

Electrochemical deposition of nickel targets from aqueous electrolytes for medical radioisotope production in accelerators: a review

Mieszkowska

Grdeń

2021

J Solid State Electrochem

View full text Add to dashboard Cite

This paper reviews reported methods of the electrochemical deposition of nickel layers which are used as target materials for accelerator production of medical radioisotopes. The review focuses on the electrodeposition carried out from aqueous electrolytes. It describes the main challenges related to the preparation of suitable Ni target layers, such as work with limited amounts of expensive isotopically enriched nickel; electrodeposition of sufficiently thick, smooth and free of cracks layers; and recovery of unreacted Ni isotopes from the irradiated targets and from used electrolytic baths.

show abstract

Implementation of a solid target production facility

Cited by 2 publications

References 0 publications

Trace Metal Impurities Effects on the Formation of [64Cu]Cu-diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]Cu-ATSM)

Trace Metal Impurities Effects on the Formation of [64Cu]Cu-diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]Cu-ATSM)

Electrochemical deposition of nickel targets from aqueous electrolytes for medical radioisotope production in accelerators: a review

Contact Info

Product

Resources

About