Airborne application of HTS SQUIDs is the most difficult environment for their successful deployment. In order to operate with the sensitivity required for a particular application, there are many issues to be addressed such as the need for very wide dynamic range electronics, motion noise elimination, immunity to large changing magnetic fields and cultural noise sources. This paper reviews what is necessary to achieve an airborne system giving examples in geophysical mineral exploration. It will consider issues relating to device design and fabrication, electronics, dewar design, suspension system requirements and noise elimination methods.