Implementation of a Medical Database System for a Radiosurgery Center

Kufeld, Markus; Fürweger, Christoph; Drexler, Christian; Wowra, B.; Muacevic, A.

doi:10.7759/cureus.4

Cited by 8 publications

(7 citation statements)

References 16 publications

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“…Notwithstanding, many patients do have contraindications for surgery like advanced age, comorbidities or side effects after prior systemic therapy, making surgery not applicable and alternative therapies must be considered. Historically, radiotherapy has been used with palliative intent with good response rates especially in terms of pain relief [ 12 , 15 ]. On the basis of technical advances in recent years, it is now possible to safely apply larger doses of radiation to adrenal tumors with a limited number of fractions.…”

Section: Discussionmentioning

confidence: 99%

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Robotic Radiosurgery for Adrenal Gland Metastases

Haidenberger¹,

Heidorn²,

Kremer³

et al. 2017

Cureus

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IntroductionThe purpose of this study was to investigate the safety and efficacy of CyberKnife (CK) robotic radiosurgery for treatment of adrenal metastases.MethodsWe performed a retrospective analysis of 23 patients with adrenal metastases who had been treated with CK between October 2006 and December 2015. Fifteen patients received chemotherapy prior to radiosurgery, all patients underwent computer tomography (CT) fluoroscopically guided percutaneous placement of one to three gold fiducials into the adrenal gland. Nineteen patients were selected for single-fraction radiosurgery with a median dose of 22 Gy, four patients were treated in three fractions with a median dose of 13.5 Gy.ResultsMedian follow-up time was 23.6 months. Four patients (17%) experienced local relapse during the evaluation period with a mean time of 19 months to tumor progression. The actuarial local tumor control rate was 95% after one year and 81% after two years. Three of the four patients with local recurrence were retreated with CK radiosurgery. Dynamic tumor tracking enabled accurate treatment with correlation errors less than 2 mm, despite extensive respiration-induced target motion up to 22 mm. Apart from nausea directly after treatment in five patients, we observed no early or late treatment-related side effects.ConclusionsSingle fraction robotic radiosurgery for adrenal gland metastases is a safe and effective treatment option for patients who are not eligible for surgical resection.

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Section: Discussionmentioning

confidence: 99%

“…Patient characteristics, treatment, and follow-up data were collected in a dedicated medical database that has been described previously [ 12 ].…”

Section: Methodsmentioning

confidence: 99%

Robotic Radiosurgery for Adrenal Gland Metastases

Haidenberger¹,

Heidorn²,

Kremer³

et al. 2017

Cureus

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“…The treatment records of 1,378 patients with 1,384 VS treated with CyberKnife-based SRS (Accuray Inc., Sunnyvale, CA) at the European CyberKnife Center in Munich between 2005 and 2018 were collected in a database for SRS [8]. CyberKnife is a frameless, image-guided robotic SRS system [9].…”

Section: Methodsmentioning

confidence: 99%

Clinical Results After Single-fraction Radiosurgery for 1,002 Vestibular Schwannomas

Windisch¹,

Tonn²,

Fürweger³

et al. 2019

Cureus

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Background Herein, we report clinical results for patients treated with stereotactic radiosurgery (SRS) for vestibular schwannomas (VS) over a period of 10 years. Methods Clinical data and imaging follow-up were stored in a database of 1,378 patients, with 1,384 VS treated consecutively between 2005 and 2018 and analyzed retrospectively. A total of 996 patients with 1,002 tumors with at least one year of follow-up were included for analysis. Results Median follow-up was 3•6 years (1-12•5 years). The three, five, and 10-year Kaplan-Meier estimated local tumor control was 96•6%, 92•3%, and 90•8%, respectively. The median hearing loss of the affected ear as compared to its healthy counterpart was 17 dB at treatment start and increased to 23 and 29 dB at one and five years. Six patients (0•6%) developed symptomatic hydrocephalus and underwent the placement of a ventriculoperitoneal shunt. In 30 patients (3•0%), trigeminal sensory dysfunction developed, five patients (0•5%) had a mild transient weakness, and nine patients (0•9%) had a permanent facial weakness (House-Brackmann Grade > II) after SRS. Conclusion Single fraction SRS proves to be highly effective and shows low treatment-related toxicity for VS. SRS should be considered a primary treatment option for small and middle-sized VS.

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“…The treatment records of 1569 patients with VS treated with CyberKnife-based SRS (Accuray Inc., Sunnyvale, CA, USA) at the European Cyberknife Center in Munich between 2005 and 2019 were collected in a database for SRS [ 23 ]. CyberKnife is a frameless, image-guided robotic SRS system [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Longitudinal Changes of Quality of Life and Hearing Following Radiosurgery for Vestibular Schwannoma

Windisch

Tonn

Fürweger

et al. 2021

Cancers

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Background: Most existing publications on quality of life (QoL) following stereotactic radiosurgery (SRS) for vestibular schwannomas (VS) gather information retrospectively by conducting surveys several years after treatment. The purpose of this study is therefore to provide longitudinal QoL data and assess how changes in hearing impact QoL. Methods: Patients completed the 12-item short-form (SF-12) health survey prior to treatment and at every follow-up visit. One hundred and seventy-five patients who had complete forms prior to treatment as well as at an early and at a late follow-up were included in the analysis. For 51 of these patients, longitudinal audiometry data were available. Results: Median follow-up was 7.2 years. Patients experienced a significant reduction in the physical composite score (PCS, p = 0.011) compared to before treatment. The mental composite score (MCS) increased significantly (p = 0.032). A decrease in PCS was not significantly correlated with an increased hearing threshold on the affected but rather on the unaffected ear (r(49) = −0.32, p = 0.023). Conclusions: It is unclear whether the decline in the PCS is due to treatment-related toxicity or the normal decline of PCS with age. Ensuring proper hearing on the untreated ear might be crucial to ensure good QoL for patients treated with SRS for VS, though this association should be confirmed in additional studies.

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Implementation of a Medical Database System for a Radiosurgery Center

Cited by 8 publications

References 16 publications

Robotic Radiosurgery for Adrenal Gland Metastases

Robotic Radiosurgery for Adrenal Gland Metastases

Clinical Results After Single-fraction Radiosurgery for 1,002 Vestibular Schwannomas

Longitudinal Changes of Quality of Life and Hearing Following Radiosurgery for Vestibular Schwannoma

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