Implementation of a hospital-wide project for appropriate antimicrobial prophylaxis

Treatment options for methicillin-resistant Staphylococcus aureus (MRSA) infection: Where are we now?

“…Renal failure. Although linezolid requires no dose adjustment in renal failure, haematological toxicity was more frequent in patients with end-stage renal disease than in those with non-endstage renal disease [83,84], and in a general population with sepsis a creatinine clearance of <50 mL/min was an independent predictor of thrombocytopenia [85]. It would be reasonable that linezolid clearance is decreased in patients with low glomerular filtration.…”

Application of ATC/DDD methodology to evaluate perioperative antimicrobial prophylaxis

“…Despite prolonged duration of surgical antimicrobial prophylaxis, it does not reduce the rate of SSI; many surgeons have a tendency to use prophylaxis longer than recommended [1,7,10,11,20,21]. In studies conducted in 2001 and 2002 in our hospital, Yalcin et al found that duration of prophylaxis was appropriate only in 47.7 and 29.0% of all cases, respectively [12,14].…”

“…In another Dutch study, prophylactic antibiotic consumption decreased from 0.75 to 0.53 DDD per operation [21]. In a Japanese study, DDD per 100 procedures decreased from 160.6 to 129 following intervention [1]. Hosoglu et al calculated the density of PAP as 330.2 DDD/100-operation at a general hospital in central Diyarbakir, a city in south-eastern Turkey [11].…”

“…The results of the present study therefore indicate no change in duration of surgical prophylaxis for approximately 9 years in our hospital. In other studies, the incorrect duration of surgical prophylaxis ranged between 45 and 87.9% [1,2,20]. In another study from Turkey, the duration of surgical antimicrobial prophylaxis was reported as being less than 24 h for only 20% of the selected procedures [10].…”

“…In many surgical procedures, perioperative antimicrobial prophylaxis (PAP) has been found to be effective in reducing the incidence of surgical site infections (SSI) [1,2]. In many countries, the guidelines for PAP have been improved, based on international experiences and guidelines [3][4][5].…”