Implementation of a Fully Automated Latex Immunoturbidimetric Assay for the Diagnosis of Heparin-Induced Thrombocytopenia in a High-Volume University Hospital Laboratory
Abstract:Background
Heparin-induced thrombocytopenia (HIT) is an immune-mediated, adverse reaction to heparin in which heparin binds platelet factor 4 (PF4), triggering the development of heparin-PF4 antibodies (HITAb). HITAbs bind and activate platelets, causing thrombosis, platelet consumption, and thrombocytopenia. Heparin is replaced with relatively costly nonheparin anticoagulants until HIT can be ruled out. HIT diagnosis consists of a HITAb immunoassay with reflex to a serotonin release assay (S… Show more
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