“…Several studies have shown that Ti implants with a biomimetic surface topography result in improved osseointegration in animal models that exhibit a compromised bone quality compared to implants with a smooth topography created by machining [ 33 , 34 , 35 , 36 ]. Most of these studies have used rats or mice with an induced diabetic phenotype or an osteoporotic phenotype resulting from ovariectomy [ 12 , 13 , 33 , 34 , 35 , 36 ]. A compromised bone quality can also result from disuse or mechanical unloading situations, which can be caused by long-term bed rest, neuromuscular injuries, space flight, or spinal cord injuries [ 15 , 37 , 38 , 39 ].…”