Implanted subcutaneous versus intraperitoneal bioscaffold seeded with hepatocyte-like cells: functional evaluation

Fares, Amal Elham; Gabr, Hala; ShamsEldeen, Asmaa Mohammed; Farghali, Haithem A.; Rizk, Mazen Mohamed Salem Mohamed; Mahmoud, Bassem Essam; Tammam, Ahmed Bakr Ahmed; Mahmoud, Ayman Magdy Ahmed; Suliman, Alaa Abdulfattah Mahmoud; Ayyad, Mohamed; Ahmed, Sahar; Hassan, Rokia

doi:10.1186/s13287-021-02531-2

Cited by 3 publications

(1 citation statement)

References 32 publications

(37 reference statements)

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“…Decellularized ovarian extracellular matrix is another natural matrix, obtained by removing the cellular components from the natural ovary, which can highly mimic the natural ovary in vivo allow cells to adhere and grow. Decellularized tissue has been tested in the liver ( 69 ), lung ( 70 ), and heart ( 71 ). Nevertheless, xenotransplantation may induce the immune reaction in the human body and should be paying more attention to further clinical application.…”

Section: Strategies For Fertility Preservationmentioning

confidence: 99%

Artificial Ovary for Young Female Breast Cancer Patients

et al. 2022

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In recent decades, there has been increasing attention toward the quality of life of breast cancer (BC) survivors. Meeting the growing expectations of fertility preservation and the generation of biological offspring remains a great challenge for these patients. Conventional strategies for fertility preservation such as oocyte and embryo cryopreservation are not suitable for prepubertal cancer patients or in patients who need immediate cancer therapy. Ovarian tissue cryopreservation (OTC) before anticancer therapy and autotransplantation is an alternative option for these specific indications but has a risk of retransplantation malignant cells. An emerging strategy to resolve these issues is by constructing an artificial ovary combined with stem cells, which can support follicle proliferation and ensure sex hormone secretion. This promising technique can meet both demands of improving the quality of life and meanwhile fulfilling their expectation of biological offspring without the risk of cancer recurrence.

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Section: Strategies For Fertility Preservationmentioning

confidence: 99%

Artificial Ovary for Young Female Breast Cancer Patients

et al. 2022

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Prospects for fertility preservation: the ovarian organ function reconstruction techniques for oogenesis, growth and maturation in vitro

Wang

et al. 2023

Front. Physiol.

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Today, fertility preservation is receiving more attention than ever. Cryopreservation, which preserves ovarian tissue to preserve fertility in young women and reduce the risk of infertility, is currently the most widely practiced. Transplantation, however, is less feasible for women with blood-borne leukemia or cancers with a high risk of ovarian metastasis because of the risk of cancer recurrence. In addition to cryopreservation and re-implantation of embryos, in vitro ovarian organ reconstruction techniques have been considered as an alternative strategy for fertility preservation. In vitro culture of oocytes in vitro Culture, female germ cells induction from pluripotent stem cells (PSC) in vitro, artificial ovary construction, and ovaria-related organoids construction have provided new solutions for fertility preservation, which will therefore maximize the potential for all patients undergoing fertility preservation. In this review, we discussed and thought about the latest ovarian organ function reconstruction techniques in vitro to provide new ideas for future ovarian disease research and fertility preservation of patients with cancer and premature ovarian failure.

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Preparation and Use of Decellularized Extracellular Matrix for Tissue Engineering

McInnes

Möser

Chen

2022

JFB

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The multidisciplinary fields of tissue engineering and regenerative medicine have the potential to revolutionize the practise of medicine through the abilities to repair, regenerate, or replace tissues and organs with functional engineered constructs. To this end, tissue engineering combines scaffolding materials with cells and biologically active molecules into constructs with the appropriate structures and properties for tissue/organ regeneration, where scaffolding materials and biomolecules are the keys to mimic the native extracellular matrix (ECM). For this, one emerging way is to decellularize the native ECM into the materials suitable for, directly or in combination with other materials, creating functional constructs. Over the past decade, decellularized ECM (or dECM) has greatly facilitated the advance of tissue engineering and regenerative medicine, while being challenged in many ways. This article reviews the recent development of dECM for tissue engineering and regenerative medicine, with a focus on the preparation of dECM along with its influence on cell culture, the modification of dECM for use as a scaffolding material, and the novel techniques and emerging trends in processing dECM into functional constructs. We highlight the success of dECM and constructs in the in vitro, in vivo, and clinical applications and further identify the key issues and challenges involved, along with a discussion of future research directions.

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Implanted subcutaneous versus intraperitoneal bioscaffold seeded with hepatocyte-like cells: functional evaluation

Cited by 3 publications

References 32 publications

Artificial Ovary for Young Female Breast Cancer Patients

Artificial Ovary for Young Female Breast Cancer Patients

Prospects for fertility preservation: the ovarian organ function reconstruction techniques for oogenesis, growth and maturation in vitro

Preparation and Use of Decellularized Extracellular Matrix for Tissue Engineering

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